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Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Creator:

Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.

Abstract:

Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...

Resource Type:

Article

Full Text:

): e65250. doi:10.1371/journal.pone.0065250 Editor: Ben C.B. Ko, Chinese University of Hong Kong, Hong Kong