Index Catalog // ScholarsArchive@OSU

Creator:: Murphy, Michael C.
Abstract:: This paper presents a brief discussion on the phenomenon of exercise-induced insulin sensitization, including the effects of exercise on insulin-stimulated glucose uptake and potential mechanisms mediating these effects. Originally created for KIN 481 (Writing Intensive Curriculum course).
Resource Type:: Research Paper
Full Text:: . https://doi.org/10.1172/JCI111938 DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J

Creator:: Trias, Emiliano, Beilby, Pamela R., Kovacs, Mariangeles, Ibarburu, Sofia, Varela, Valentina, Barreto-Nunez, Romina, Bradford, Samuel C., Beckman, Joseph S., and Barbeito, Luis
Abstract:: Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic role of cellular senescence in ALS remains poorly understood. In rats bearing the ALS-linked...
Resource Type:: Article

Creator:: Dasari, Surendra, Newsom, Sean A., Ehrlicher, Sarah E., Stierwalt, Harrison D., and Robinson, Matthew M.
Abstract:: Excess fat intake can increase lipid oxidation and expression of mitochondrial proteins, indicating remodeling of the mitochondrial proteome. Yet intermediates of lipid oxidation also accumulate, indicating a relative insufficiency to completely oxidize lipids. We investigated remodeling of the mitochondrial proteome to determine mechanisms of changes in lipid oxidation following high-fat...
Resource Type:: Article

Creator:: Beer, Sofia R.
Abstract:: Acute myeloid leukemia (AML) is a blood malignancy characterized by a differentiation and proliferation defect of myeloid progenitors leading to accumulation of myeloid blasts. It is one of the most common leukemias in adults. Trametinib (Mekinist) is a small molecule inhibitor that targets MEK1 (MAP2K1) and MEK2 (MAPK2K2). It has...
Resource Type:: Honors College Thesis
Full Text:: investigation, 108(6), 851– 859. doi:10.1172/JCI12807 7. Leukemia. (2019). Retrieved June 21, 2019, from

Creator:: Cummings, Brittany M., Needoba, Joseph A., and Peterson, Tawyna D.
Abstract:: Many pharmaceuticals have negative effects on biota when released into the environment. For example, recent work has shown that the commonly prescribed antidiabetic drug, metformin (N,N-dimethylbiguanide), has endocrine disrupting effects on fish. However, effects of metformin on aquatic primary producers are poorly known. We exposed cultured isolates of a freshwater...
Resource Type:: Article
Full Text:: . Invest. 2001; 108(8): 1167–1174. https://doi.org/10.1172/ JCI13505 PMID: 11602624 29. Owen MR, Doran E

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article

Creator:: Roquis, David, Lepesant, Julie M. J., Picard, Marion A. L., Freitag, Michael, Parrinello, Hugues, Groth, Marco, Emans, Rémi, Cosseau, Céline, and Grunau, Christoph
Abstract:: Background: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a...
Resource Type:: Article

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