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Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics

Creator:

Bonventre, Josephine A., Zielke, Ryszard A., Korotkov, Konstantin V., and Sikora, Aleksandra E.

Abstract:

A promising new drug target for the development of novel broad-spectrum antibiotics is the highly conserved small GTPase Obg (YhbZ, CgtA), a protein essential for the survival of all bacteria including Neisseria gonorrhoeae (GC). GC is the agent of gonorrhea, a prevalent sexually transmitted disease resulting in serious consequences on...

Resource Type:

Article