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Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Creator:

Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.

Abstract:

DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...

Resource Type:

Article