Benzo[a]pyrene (B[a]P) is a common environmental pollutant produced from the incomplete combustion of organic matter, such as fossil fuel emissions. In vertebrates, B[a]P exposure is associated with hyperactivity, though the underlying mechanisms driving this effect are undescribed. Mounting evidence indicates that the gut microbiome, which is the diverse community of...
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex and spinal cord. Recent evidence suggests that the purine receptor P2X7 (P2X7R) plays a central role in the pathology of ALS. Previous research indicates that P2X7R activation by oxidatively modified heat shock protein 90...
In the wake of the ``third wave'' of democratization, scholars and practitioners were optimistic regarding the ease with which countries could adopt democratic norms and institutions. However, after four decades of democracy, many competitive regimes have not improved government probity or developed strong forms of accountability. Levels of economic and...
Dwelling on the bottom of large rivers to high alpine streams, freshwater sculpins (genus Cottus) occur in high densities across the Pacific Northwest, with 21 currently recognized species found in the Pacific Northwest. Sculpin fill many ecological roles, with some species serving as important prey sources, and others competing with...
BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
Humans have always been fascinated with whales; from prominent features in mythology, to stories of terrifying monsters on the high seas, to globalized utility, to symbolic wildness and radical environmentalism, to figures and statistics, how have human relationships with whales been understood throughout time? Because humans have a need to...
The objective of this paper was to measure and compare the heat transfer coefficient and pressure drop of R404A and two potential replacement candidate refrigerants with a lower global warming potential, R448A and R452A. Experiments were conducted inside a 4.7 mm horizontal tube at mass fluxes ranging from 100 to...
Heat transfer coefficients and frictional pressure drop values are experimentally measured during condensation of R134a and its proposed low global warming potential (GWP) replacement, R450A. R450A is a non-flammable zeotropic mixture of R134a and R1234ze (42/58% by mass). Experiments were conducted in a horizontal tube (ID = 4.7 mm) for...
Sea otters fulfill a keystone role in several Northeastern Pacific nearshore ecosystems. However, their influence has been absent in Oregon coastal waters since their extirpation in the 19th and early 20th century. Interest has been growing for a translocation attempt to reintroduce sea otters to Oregon from one or more...