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Filtering by: Creator Kuhl, Joseph C. License Attribution-NonCommercial-NoDerivs 3.0 United States

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

Creator:

Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.

Abstract:

The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...

Resource Type:

Article

Full Text:

that depletion of C- MYC in human melanoma cells led to the induction of senescence-associated