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Filtering by: Creator Larsson, Lena C. License Attribution-NonCommercial-NoDerivs 3.0 United States Commencement Year Unknown

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

Creator:

Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.

Abstract:

The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...

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that depletion of C- MYC in human melanoma cells led to the induction of senescence-associated
Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

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White, Angelicque E., Letelier, Ricardo M., Whitmire, Amanda L., Barone, Benedetto, Bidigare, Robert R., Church, Matthew J., and Karl, David M.

Abstract:

The particle size distribution (PSD) is a critical aspect of the oceanic ecosystem. Local variability in the PSD can be indicative of shifts in microbial community structure and reveal patterns in cell growth and loss. The PSD also plays a central role in particle export by influencing settling speed. Satellite-based...

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(c) and n5 1.17 (e). Data are binned to 2 m depth bins, and each sample represents the median of all

ScholarsArchive@OSU

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

Phenology of particle size distributions and primary productivity in the North Pacific subtropical gyre (Station ALOHA)

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