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Filtering by: Creator Long, Deng Non-Academic Affiliation Linus Pauling Institute Peer Reviewed No

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:

Riordan, Ruben

Abstract:

Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...

Resource Type:

Dissertation

Full Text:

resulted in a mild long-term memory deficit. Elimination of Nrf2 did not increase senescent cell burden
Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:

Paraiso, Ines L.

Abstract:

Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...

Resource Type:

Dissertation

Full Text:

and drug administration (FDA) for long-term use include Orlistat (Xenical®), a pancreatic lipase