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Filtering by: Creator Randall, Warren R. Non-Academic Affiliation Linus Pauling Institute Resource Type Dissertation

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:

Paraiso, Ines L.

Abstract:

Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...

Resource Type:

Dissertation

Full Text:

synthesis by reducing CYP7A1 expression via SHP, 2) decreases PCSK9 expression, thereby inducing LDL-R