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Filtering by: DOI 10.1172/JCI62070 Non-Academic Affiliation Linus Pauling Institute

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:

Lytle, Kelli A. and Jump, Donald B.

Abstract:

Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...

Resource Type:

Article
The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:

Riordan, Ruben

Abstract:

Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...

Resource Type:

Dissertation