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Filtering by: Publisher Royal Astronomical Society Non-Academic Affiliation Linus Pauling Institute

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Creator:

Zhu, Ben-Zhan, Chao, Xi-Juan, Huang, Chun-Hua, and Li, Yan

Abstract:

The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...

Resource Type:

Article