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Filtering by: Creator Sullivan, Nichole D. Non-Academic Affiliation Linus Pauling Institute

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:

Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.

Abstract:

Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...

Resource Type:

Article

Full Text:

E. Williams1,2, Emily Ho2,4, Roderick H. Dashwood1,2, Abby D. Benninghoff3,5,6* 1 Department of
The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:

Riordan, Ruben

Abstract:

Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...

Resource Type:

Dissertation