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Filtering by: Creator Xu, Ling Non-Academic Affiliation Linus Pauling Institute

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:

Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.

Abstract:

Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...

Resource Type:

Article

Full Text:

4: e6469. 14. Xu K, Zheng X, Sehgal A (2008) Regulation of feeding and metabolism by neuronal and
The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:

Riordan, Ruben

Abstract:

Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...

Resource Type:

Dissertation

Full Text:

, Xu et al., 2015). Rapamycin is believed to be able to inhibit components of the SASP by activating