Index Catalog // ScholarsArchive@OSU

Genetic variation of Renibacterium salmoninarum genes in infected salmonids

Creator:: Burnett, Jeffrey R.
Abstract:: Renibacterium salmoninarum is the causative agent of bacterial kidney disease in both wild and farmed salmonid species worldwide. The genome of this pathogen has significant synteny to the ubiquitous, soil-dwelling Arthrobacter spp. though it is 1.9 Mb smaller, suggesting that reductive evolution has occurred. Recently, our group finished sequencing and...
Resource Type:: Undergraduate Thesis and Presentation

Characterization of a Sporulation-Specific Kinase in Clostridium perfringens

Creator:: Danielson, Bryan
Abstract:: Clostridium perfringens type A isolates produce the spore-specific enterotoxin, CPE, upon sporulation in the gastrointestinal tract of humans and animals. Spo0A is a response regulator representing the major transcription factor for sporulation initiation in C. perfringens. In Bacillus subtilis, a multicomponent phosphorelay involving five histidine kinases (KinA-KinE), the intermediate response...
Resource Type:: Undergraduate Thesis and Presentation

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Creator:: Bratton, Daniel
Abstract:: The oilseed crop Limnanthes alba (white meadowfoam) is grown in Oregon. Methods were developed for the production of a liquid-based bioherbicide from meadowfoam seed meal (MSM). It was determined that glucosinolate-containing extracts of MSM can be combined with active-enzyme-containing liquid extracts of meadowfoam seed to form a fermented product rich...
Resource Type:: Undergraduate Thesis
Full Text:: Bioherbicidal Breakdown Products By Daniel Bratton An Undergraduate

Immunohistochemical characterization of melanomas in bigenic mice containing activated Cdk4 and keratinocyte specific ablation of Retinoid-X-Receptor alpha (RXRα) protein With international consideration of Differences in Societal and Behavioral Attitudes toward Skin Cancer between Japanese American and Japanese

Creator:: Nguyen, Vananh M.
Abstract:: OVERVIEW OF INTRODUCTION - This is a combined thesis for both disciplines of BioResource Research (BRR)Interdisciplinary and International Degree (ID) Programs OSU. The first chapter encompasses the BRR research, which is a preliminary study utilizing immunohistochemical method to characterize melanomas in bigenic mice with activated Cdk4 protein and Retinoid-X-Receptor α...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: melanoma (Kamb et al., 1994) through a point mutation of arginine (R) to cystine (C) (Cdk4 R24C/R24C

Targeting Chemotherapeutic Resistance through Bcl-2

Creator:: Avery, Jonathan, Pearce, Martin, and Kolluri, Siva
Abstract:: Access restricted, at author's request, until June 20, 2021 due to proprietary information.
Resource Type:: Presentation
Full Text:: : Daniel Weber When the apoptotic pathway is impaired the cells will not die when the death signal is

Combinational Effects of Retinoid-X-Receptor α (RXRα) Ablation with Oncogenic Mutations Cdk4[Superscript R24C/R24C] or N-Ras[Superscript Q61K/Q61K] after Ultraviolet Radiation Induced Melanoma Development, Combinational Effects of Retinoid-X-Receptor α (RXRα) Ablation with Oncogenic Mutations Cdk4R24C/R24C or N-RasQ61K/Q61K after Ultraviolet Radiation Induced Melanoma Development

Creator:: Sherman, Anna
Abstract:: Summary Recent research has identified Retinoid-X-Receptorα (RXRα), a nuclear receptor involved in ligand mediated transcription, as having a protective function against the malignant transformation of melanocytes after treatment with chemical carcinogens. This study used mice selectively lacking keratinocytic RXRα in combination with an oncogenic mutation, either Cdk4[Superscript R24C/R24C] or N-Ras[Superscript...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: Sherman1,3, Daniel Coleman2,3, Stephen Hyter2,3, Gitali Indra3 and Arup Indra3,4 BioResource Research

Characterizing PM2.5 with Different Source Contributions

Creator:: Perez, Allison Mae S.
Abstract:: Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Resource Type:: Honors College Thesis

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Creator:: Galbreath, Amanda
Abstract:: There is a growing need to establish alternative approaches for assessing hazard from chemical exposure compared to the traditional method of animal testing. Approaches that relate chemical structure to biological activity are gaining acceptance in the field as in silico methods for characterizing and predicting chemical toxicity. In this study,...
Resource Type:: Undergraduate Thesis
Full Text:: values that are present within the correlation image (Fig. 2) “r” and “p” represent two describing

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Creator:: Snow, Erika
Abstract:: Respiratory illnesses caused by both viral and bacterial infection are serious issues for global healthcare providers. With the emergence of new, drug-resistant forms of these diseases, innovative drugs and treatment therapies are needed. M tuberculosis is an infection that affects a large portion of the world’s population each year. Aerosol...
Resource Type:: Honors College Thesis
Full Text:: BioResource Research Daniel Arp, Dean, University Honors College I

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Honors College Thesis
Full Text:: 150 R el at iv e Su rv iv al (% ) BPDE Dose (nM) DLD1 (MSH6-) DLD1+Ch2 (MSH6+) 0 50 100 150

Geographic variation in the seed mycobiome of Coastal Douglas-fir (Pseudotsuga menziesii var. menziesii)

Creator:: Bergmann, Gillian E.
Abstract:: Seeds are an essential component of plant life histories, and seed endophytes have the potential to influence germination, seedling establishment and development. That said, seed endophytes are a relatively new area of study, both in the factors that influence which taxa are present and how these microbes alter plant function....
Resource Type:: Honors College Thesis
Full Text:: performed using R 3.5.2 (R Core Team 2016, GGPLOT2 package). To determine if there was an association

ScholarsArchive@OSU

Genetic variation of Renibacterium salmoninarum genes in infected salmonids

Characterization of a Sporulation-Specific Kinase in Clostridium perfringens

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Targeting Chemotherapeutic Resistance through Bcl-2

Characterizing PM2.5 with Different Source Contributions

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Geographic variation in the seed mycobiome of Coastal Douglas-fir (Pseudotsuga menziesii var. menziesii)

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