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Filtering by: Creator Kuriyama, Y. Remove constraint Creator: Kuriyama, Y. Non-Academic Affiliation Oregon State University. Bioresource Research Remove constraint Non-Academic Affiliation: Oregon State University. Bioresource Research

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  • Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

    Creator:
    You, Hyekyoung Hannah
    Abstract:
    Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
    Resource Type:
    Honors College Thesis
    Full Text:
    272 (30): 18702–8. Shimada, T., and Y. Fujii-Kuriyama. 2004. “Metabolic Activation of Polycyclic