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Filtering by: Creator Brenner, Michael A. Remove constraint Creator: Brenner, Michael A. Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School Subject Alkaloids -- Synthesis Remove constraint Subject: Alkaloids -- Synthesis

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Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

Creator:

Collett, Nathan D.

Abstract:

Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...

Resource Type:

Dissertation

Full Text:

Related Natural Products, a Michael Reaction Focused Approach. AN ABSTRACT OF THE DISSERTATION OF
Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

Creator:

Carlson, Erik

Abstract:

Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...

Resource Type:

Masters Thesis

Full Text:

Michael Addition and Application Towards Alkaloid Synthesis by Erik Carlson A THESIS
Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:

Veerasamy, Nagarathanam

Abstract:

The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...

Resource Type:

Dissertation

Full Text:

synthetic sequence include the use of an organocatalyzed aza- Michael addition to access a common
A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

Creator:

Saha, Mrinmoy

Abstract:

Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....

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Dissertation

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organocatalyzed intramolecular Michael reaction, formation of tricyclic skeleton using a conformationally
Studies toward the synthesis of halichlorine and pinnaic acid

Creator:

Korf, Eric A.

Abstract:

Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...

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Dissertation

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acrylate moiety. It was shown that continued heating favors a reversible Michael addition which delivers
Studies on nitrogen containing secondary metabolites from terrestrial and marine origin

Creator:

Barrios Sosa, Ana Carolina

Abstract:

PART I. A deuterium exchange analysis of 2,5-dihydroxyacetanilide (5) in the absence and presence of DHAE II was performed to test the nucleophilicity of the substrate in the absence and presence of catalyst. In addition, inhibition studies using 1,4-dihydroxybenzene were performed to determine the role that the N-acetyl side chain...

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Dissertation

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Abstract approved: David A. Home Kevin P. Gable PART I. A deutenum exchange analysis of 2,5
Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Creator:

Melbardis, John

Abstract:

In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...

Resource Type:

Masters Thesis

Full Text:

Featuring a connective Michael reaction as a key step, Michael acceptor 65 was prepared in three steps
Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:

Tonsiengsom, Sorasaree

Abstract:

Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...

Resource Type:

Dissertation

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features to introducing the CBD tricycles are a Sharpless/Kresze allylic amination, internal Michael
Synthetic studies on alkaloids : part I; asymmetric synthesis of (±) codeine. Formal synthesis of (±) morphine : part II; a unified asymetric approach toward synthesis of polyhydroxylated pyrrolizidine alkaloids, australine and alexine

Creator:

Hrnciar, Peter

Resource Type:

Dissertation

Full Text:

Alkaloids. Part I: Asymmetric Synthesis of (+)- Codeine. Formal Synthesis of (+)-Morphine. Part II: A
An approach toward the synthesis of euonyminol and cathedulin K- 19

Creator:

Shin, Hyunik

Abstract:

A synthetic approach toward the two major fragments of cathedulin K-19, euonyminol (4) and dimethyl cathate (69), was investigated. Synthesis of dimethyl cathate was accomplished in 3 steps starting from 73. Efforts directed towards the synthesis of euonyminol, a highly oxygenated dihydroagarofuran sesquiterpene, was advanced to a stage in which...

Resource Type:

Dissertation

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preparation of epoxy enone 91, which would be functionalized to yield 92 via a Michael 30 addition and

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Academic Affiliation

Chemistry14

Advisor

White, James D.6
Carter, Rich G.4
Gable, Kevin P.2
Blakemore, Paul R.1
Horne, David A.1
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Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1993 to 2016

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Committee Member

Blakemore, Paul3
Gable, Kevin3
Blakemore, Paul R.2
Deinzer, Max2
Lerner, Michael M.2
more Committee Members »

Creator

Barrios Sosa, Ana Carolina1
Carlson, Erik1
Collett, Nathan D.1
Hansen, Joshua D.1
Hrnciar, Peter1
more Creators »

Date

Date range begin – Date range end

Current results range from 1993 to 2015

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Decade

2010-20193
2000-20096
1990-19995

Degree Field

Chemistry14

Degree Level

Doctoral12
Master's2

Degree Name

Doctor of Philosophy (Ph.D.)12
Master of Science (M.S.)2

File Format

application/pdf2

Language

English [eng]14

License

All rights reserved9

Non-Academic Affiliation

Oregon State University. Graduate School[remove]14

Peer Reviewed

No12

Resource Type

Dissertation12
Masters Thesis2

Rights Statement

In Copyright9
Copyright Not Evaluated5

Subject

Alkaloids -- Synthesis[remove]14
Marine metabolites -- Synthesis2
Morphine -- Synthesis2
Acetanilide1
Approach toward the synthesis of (̳+)-koumine1
more Subjects »

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