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Filtering by: Creator Gómez, Walter Non-Academic Affiliation Oregon State University. Graduate School Subject Vitamin D -- Receptors

Role of Melanocytic Vitamin D Receptor (VDR) in UVB-induced Melanocyte Homeostasisand Keratinocytic Retinoid–X-Receptor α (RXRα) in UVB Induced Melanomagenesis

Creator:

Chagani, Sharmeen

Abstract:

Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...

Resource Type:

Dissertation
Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:

Guo, Chunxiao

Abstract:

Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...

Resource Type:

Dissertation