Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a
complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases)
enzymes. One approach to separating these enzymes is affinity chromatography. A new
ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose.
The property of APTC in affinity chromatography is demonstrated using Trichoderma...
In this thesis, we examined the effects of the exposures to anthropogenic pollutants on the fish, primarily juvenile chinook salmon, immune system using newly and recently developed immune assays. In addition, we developed a new assay for measuring immunocompetence of fish. In the first chapter, the Alamar Blue assay was...
Workers in colonies of European honey bees Apis mellifera L. clean their
nestmate's body by allogrooming behavior. This behavior may be initiated by
either grooming dancers or by the allogroomers themselves. The first occurs
less frequently (ca. 17 %) than the later (83 %). By using the inner edge of...
An empirical statistical model is developed that relates the non-tidal motion of the ocean surface currents off the Oregon coast to forecasts of the coastal winds. The empirical statistical model is then used to produce predictions of the surface currents that are evaluated for their agreement with measured currents. Measurements...
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P. Michael Kosro
An empirical statistical model is developed that relates the non-tidal
Time-dependent electronic transport is increasingly important to the state-of-the-art device design and fabrication. The development of nanoscale sensing, the harnessing and control of structural fluctuations, and the advancement of next-generation materials all require a treatment of quantum dynamics beyond the level of traditional methods and a more nuanced approach to...
Coastal-based high-frequency (HF) radar systems are an increasingly used tool for measuring surface currents in the coastal ocean. These systems provide a spatial and temporal resolution not achievable with other methods. Standard-range sites typically generate hourly maps of surface currents on a 2km grid extending approximately 50km from shore while...
Although science is widely accepted as a fundamental source of information underlying decisions about forest management and conservation, considerably less attention has been paid to the inevitable role that normative values and beliefs play in such decisions. This thesis highlights the normative dimensions of "ecological forestry," a strategy of forest...