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Filtering by: Creator Greenwood, Jeffrey A. Remove constraint Creator: Greenwood, Jeffrey A. Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School

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  • Cytoskeletal regulation in cell motility and invasion

    Creator:
    Jang, Hyo Sang
    Abstract:
    Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
    Resource Type:
    Dissertation
    Full Text:
    and Invasion Abstract approved: Jeffrey A. Greenwood Cell motility and invasion are important for

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
    Resource Type:
    Dissertation
    Full Text:
    Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
    Resource Type:
    Dissertation
    Full Text:
    M. Hagen Hallmarks of aging include the accumulation of aberrant proteins and a lower

  • Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

    Creator:
    Serrill, Jeffrey D.
    Abstract:
    Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
    Resource Type:
    Dissertation
    Full Text:
    against Glioblastoma Cells by Jeffrey D. Serrill A DISSERTATION submitted to Oregon State

  • Determination of fluorinated alkyl substances in aqueous systems

    Creator:
    Schultz, Melissa M.
    Abstract:
    Fluorinated alkyl substances, which can be persistent, toxic, and bioaccumulative, have been quantitated in many densely populated and remote regions, including in air, surface waters, groundwater, and biota; however, little is known about their transport or behavior in the environment. Wastewater effluent is one of the principal routes for introducing...
    Resource Type:
    Dissertation
    Full Text:
    served on my academic committee: Dr. Vincent Remcho, Dr. John Westall, and Dr. Jeffrey Greenwood. Many

  • Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

    Creator:
    Stanley, Kerri A.
    Abstract:
    The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
    Resource Type:
    Dissertation
    Full Text:
    , Jeffrey Greenwood and Michael Borman, for their input and time I also thank past and present members

  • Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

    Creator:
    Allan, Sarah E.
    Abstract:
    Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
    Resource Type:
    Dissertation
    Full Text:
    ,  Jeffrey  Jenkins  and  Jeffrey  Greenwood,  have  put  into  this  project and advising me during my

  • Decay of atomic states strongly coupled by an oscillating field

    Creator:
    Greenwood, William Graham
    Abstract:
    Frequency distributions are calculated for the optical decay of two atomic states which are coupled by a strong, linear rf field. Both the rotating and the counter-rotating components of the field are maintained throughout the calculations. For strong fields many peaks are present in the frequency spectrum and are explained...
    Resource Type:
    Dissertation
    Full Text:
    Oscillating Field by William Graham Greenwood A THESIS submitted to Oregon State University in partial

  • Comparative phenotypic studies on vibrios of environmental origin that resemble human clinical isolates

    Creator:
    Greenwood, John David
    Abstract:
    A comparative investigation of the phenotypic properties of environmental and clinical strains of the lactose-positive human pathogen, Vibrio vulnificus, revealed that they are indistinguishable in traits commonly used for identification in clinical and public health laboratories. It has also been confirmed that there are other strains of undefined Vibrio spp.,...
    Resource Type:
    Masters Thesis
    Full Text:
    Phenotypic Studies on V. vulnificus and a Vibrio sp. Isolated from Diseased Eels in Japan John D. Greenwood

  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
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    like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and