Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol))
was developed as an antibacterial agent but was also found to induce
toxic effects in various tissues in animals and humans. Changes were
found in myelinated nerve fibers and cerebral white matter. Erythrocytes
are hemolysed in vitro. Oxidative phosphorylation is uncoupled
by HCP at concentrations less than...
This paper has two objectives. Firstly, we present the homological properties as defined by de Rham using a notion of current. We show this with the aid of the Eilenberg and Steenrod Axioms. The cohomology is defined in the usual fashion from algebraic topology. The second goal is the relationship...
This thesis tests the hypothesis that innate immunity may be enhanced
immediately following a stressful event. The experiments characterize the acute
effects of the fight or flight response on some immunological and endocrine
parameters in rainbow trout (Oncorhynchus mykiss). Plasma cortisol and
catecholamines were elevated within seconds of the initiation...
Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
In this dissertation, we investigate three numerical methods for inverting the Laplace transform. These methods are all based on the trapezoidal-type approximations to the Bromwich integral. The first method is the direct integration method: It is a straightforward application of the trapezoidal rule to the Bromwich integral, followed by convergence...
The goal of this study was to optimize a through-boring pattern that will provide adequate preservative penetration while minimizing the reduction in overall pole bending strength. Hole spacing was developed using longitudinal and transverse chemical penetration data from previous studies. Finite element analysis was used as a preliminary assessment tool...
DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...