Index Catalog // ScholarsArchive@OSU

Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Creator:: Woo, Youn-Hi
Abstract:: This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
Resource Type:: Dissertation
Full Text:: , Dr. Phil Proteau for his support, continual inspiration, and endless patience as a mentor, in

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: thank my major Professor, Philip J. Proteau, for his support, guidance, and patience throughout my

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:: Phaosiri, Chanokporn
Abstract:: The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
Resource Type:: Dissertation
Full Text:: foremost, II would like to thank my major professor, Dr. Philip Proteau for his advice, guidance, and

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:: Fernandes, Roberta P. M.
Abstract:: In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
Resource Type:: Dissertation
Full Text:: Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP

Biosynthetic studies of fungal diterpene antibiotics

Creator:: Yao, Qingmei
Abstract:: The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: __________________________________________ Philip J. Proteau The isoprenoid

Studies toward the synthesis of coibamide A and analogues

Creator:: Li, Dong
Abstract:: Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
Resource Type:: Dissertation
Full Text:: : Philip J. Proteau Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian

The relationship of a high school family life course to post school problems and marriage role expectations

Creator:: Toliver, Rena Faye
Abstract:: The purpose of this paper was to study the relationship of a high school family life course to post high school problems and marriage role expectations. The specific objective of the study was to determine whether or not there is a relationship between participation in a high school family life...
Resource Type:: Masters Thesis
Full Text:: especially grateful to Dr. J. P. O'Neill, Chairman of the Family Life Department, for his continuing

Physiological maturation as a factor related to intrapersonal relations of adolescent girls

Creator:: Mackie, Emma Jeanne
Abstract:: The purpose of this study was to investigate the relationship between physiological maturation and the intrapersonal relations of adolescent girls. The Interpersonal Check List provided the measure of self concept and ideal self concept for each subject. Subjects were 48 early-maturing and 48 late-maturing girls representing the four levels of...
Resource Type:: Masters Thesis
Full Text:: : Redacted for privacy 9(Signattiere) J. Philip O'Neill The purpose of this study was to investigate the

The emergence of racial and sexual preference in the choice of playmates by preschool children as related to sex, socioeconomic status and race

Creator:: Morris, Lesley Frances Moore
Abstract:: The primary purpose of this study was to replicate a study of Abel and Sahinkaya which investigated the emergence of race and sex preferences of upper middle socioeconomic status Caucasian children. This study provided a good match with respect to socioeconomic status, race, and sex; however, the number of subjects...
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGEMENTS The writer wishes to express her appreciation to Dr. J. Philip O'Neil, thesis advisor, for his

The relationship between specific mother-child interactions and selected aspects of language development in Head Start children

Creator:: Owen, Martha-Ann
Abstract:: The purpose of this study was to investigate the relationship between specific mother-child interactions and selected aspects of language development in "disadvantaged" children. The subjects were 19 preschool children in a summer Head Start program in Denver, Colorado. Their ages ranged from four years-nine months to five years-seven months. Eighteen...
Resource Type:: Masters Thesis
Full Text:: gratitude to all who have helped her along the way. The writer thanks: Dr. J. Philip O'Neill, Head of the

ScholarsArchive@OSU

Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

Studies on isoprenoid biosynthesis in Euglena gracilis

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Biosynthetic studies of fungal diterpene antibiotics

Studies toward the synthesis of coibamide A and analogues

The relationship of a high school family life course to post school problems and marriage role expectations

Physiological maturation as a factor related to intrapersonal relations of adolescent girls

The emergence of racial and sexual preference in the choice of playmates by preschool children as related to sex, socioeconomic status and race

The relationship between specific mother-child interactions and selected aspects of language development in Head Start children

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