Index Catalog // ScholarsArchive@OSU

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Presentation and Undergraduate Thesis

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Honors College Thesis
Full Text:: Andrew Buermeyer DNA mismatch repair (MMR) plays an important role in

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Creator:: Merschel, Andrew G.
Abstract:: Old-growth dry-mixed conifer forests are valued as habitats for late seral forest species, for the ecosystem services and landscape diversity they provide, and for their aesthetic appeal. The structure of these forests has been heavily altered by historic logging of overstory ponderosa pine and Douglas-fir. Additionally, changes in fire regime...
Resource Type:: Honors College Thesis
Full Text:: THE THESIS OF Andrew G. Merschel for the degree of Honors Baccalaureate of Science in Natural

Investigating the Role of the MutLα Endonuclease

Creator:: Mankaney, Gautam Naresh
Abstract:: Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
Resource Type:: Honors College Thesis
Full Text:: . Abstract Approved:________________________________________________________ Andrew Buermeyer Lynch

A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

Creator:: Nguyen, Andrew
Abstract:: Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair mismatches hat have escaped proofreading during DNA replication. The process of MMR is dependent on the protein heterodimer...
Resource Type:: Honors College Thesis
Full Text:: Andrew Nguyen Honors Thesis AN ABSTRACT OF THE

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:: O'Donnell, Edmond Francis
Abstract:: DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Resource Type:: Honors College Thesis
Full Text:: . Abstract Approved: Andrew Buermeyer DNA mismatch repair (MMR) is an evolutionary conserved process that

Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creator:: Wickramanayake, Anneka
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical compounds found in the environment, largely as a result of partial combustion of organic compounds. PAHs are present in the atmosphere in populated cities worldwide. Because of the health risks they create, PAHs are a global health concern. PAHs are introduced into the...
Resource Type:: Honors College Thesis
Full Text:: :____________________________________________________ Andrew Buermeyer Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical

Creating Test Baking Methods Specifically for Whole-Wheat Sourdough Breads, In the Context of Local Grain Economies

Creator:: Jansen, Victoria E.
Abstract:: Recently local grains have become an area of economic growth. Local grain products, including whole-wheat and sourdough products, are increasingly in demand for their health benefits, unique flavor profiles, and association with local food movements. These local grain economies are beginning to boom, but they lack the technical aid that...
Resource Type:: Honors College Thesis
Full Text:: Andrew Ross Recently local grains have become an area of economic growth. Local grain products

Investigating synergistic effects of climate and land-use change on the pollination of a tropical plant, Heliconia tortuosa

Creator:: Dowd, Claire E.
Abstract:: Loss of biodiversity due to the effects of climate and land-use change may have implications for pollination services. Disruption to phenological synchronicity or a reduction in the overlap in species distributions of plants and their pollinators may reduce floral resources to pollinators, forcing them to move farther distances. If pollinators...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: _____________________________________________________ Matthew G. Betts Loss of

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Creator:: Grimwood, Victoria J.
Abstract:: Endogenous circadian clock regulation is essential to normal rhythmicity, particularly the timing of hormone release in the brain. In the context of mammalian reproduction, a surge of a specific hormone, gonadotrophin-releasing hormone (GnRH), initiates a surge of luteinizing hormone (LH) from the pituitary gland, which is required for ovulation in...
Resource Type:: Honors College Thesis

ScholarsArchive@OSU

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Investigating the Role of the MutLα Endonuclease

A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creating Test Baking Methods Specifically for Whole-Wheat Sourdough Breads, In the Context of Local Grain Economies

Investigating synergistic effects of climate and land-use change on the pollination of a tropical plant, Heliconia tortuosa

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

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