Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to
maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair
mismatches hat have escaped proofreading during DNA replication. The process of MMR is
dependent on the protein heterodimer...
Wildfires can create alternative pathways for forest development, and wildfires have expanded in size, frequency, intensity, and severity across the western United States. The purpose of this paper is to compare forest development of a mature Douglas-fir forest in western Oregon across fire severities. Postburn field measurements were collected in...
DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Recently local grains have become an area of economic growth. Local grain products, including whole-wheat and sourdough products, are increasingly in demand for their health benefits, unique flavor profiles, and association with local food movements. These local grain economies are beginning to boom, but they lack the technical aid that...
Grasslands and croplands located in temperate agro-ecologies are ranked to be the best places to install solar panels for maximum energy production. Therefore, agrivoltaic systems (agricultural production under solar panels) are designed to mutually benefit solar energy and agricultural production in the same location for dual-use of land. However, both...
Miniature satellites called cubesats have been gaining increasing popularity in
both academic and private spaceflight ventures. NASA's Jet Propulsion Laboratory
has recently been accepting design proposals for a cubesat mission to Europa, where
solar and battery power would be inadequate power sources. In this thesis, a
radioisotope powered cubesat was...
Ultraviolet (UV)-protective compounds, such as mycosporine-like amino acids (MAA) are critical for the survival of marine organisms exposed to high-solar radiation. A chemically similar compound, gadusol, was discovered in eggs of the atlantic cod in 1980, and was originally thought to be derived from MAAs that had been ingested. However,...
Mycoplasma pneumoniae is the primary cause of community-acquired pneumonias, including what is commonly known as walking pneumonia. This disease affects people from all demographics, but especially children and older adults. Outbreaks are a significant public health concern and work to develop new pharmacological agents is currently being researched. How M....