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Filtering by: Committee Member Magnusson, Kathy Remove constraint Committee Member: Magnusson, Kathy Non-Academic Affiliation Oregon State University. Honors College Remove constraint Non-Academic Affiliation: Oregon State University. Honors College

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  • The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

    Creator:
    Ewton, Jessica
    Abstract:
    Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
    Resource Type:
    Honors College Thesis
    Full Text:
    Biomedical Sciences Jennifer Johns, Committee Member, representing Clinical Pathology Kathy Magnusson

  • Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

    Creator:
    Rayzman, Noa
    Abstract:
    Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

  • The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

    Creator:
    James, Teagan
    Abstract:
    Estrogen (E2) is essential for multiple physiological effects in females, ensuring maximum reproductive fitness and maintaining skeletal homeostasis. E2 has been shown to stimulate cancellous bone formation via activation of estrogen receptor alpha (ERα), an effect widely accepted to be mediated directly at bone. A recent landmark study by Herber...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

  • The Role of Nrf2 in Brain Cellular Senescence

    Creator:
    Ross, Grace K.
    Abstract:
    Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy Magnusson, Committee Member, representing ​Biomedical Sciences, College of Veterinary

  • Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

    Creator:
    Vasudevan, Anusha
    Abstract:
    Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences

  • Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

    Creator:
    Starman, Alia
    Abstract:
    Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

  • The Effect of Zinc Status and Age on Liver Health in Mice

    Creator:
    Braun, Kendra N.
    Abstract:
    Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Kathy R. Magnusson, Committee Member, representing Biomedical Sciences