Index Catalog // ScholarsArchive@OSU

Rational design of ex vivo model of thrombosis

Creator:: Patel, Ishan A.
Abstract:: When vessel walls within the vasculature are damaged, exposed extracellular matrix (ECM) proteins trigger a series of events that lead to the formation of a hemostatic plug (Andrews et al. 2004, Furie et al. 2008, Watson 2009). Thrombus formation requires an orchestrated series of receptor-mediated events facilitating platelet recruitment, platelet...
Resource Type:: Honors College Thesis
Full Text:: approved: __________________________________________ Dr. Owen McCarty When vessel

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved:_____________________________________________________ Owen McCarty Platelet

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Creator:: Thierheimer, Marisa
Abstract:: Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Owen McCarty Platelets undergo morphological changes essential to hemostasis upon activation

Effects of Inhibitors against Syk-BTK-PI3K Signaling on Platelet Function

Creator:: Lofurno, Elizabeth R.
Abstract:: Tyrosine kinases mediate response of blood cells to stimuli and small molecule tyrosine kinase inhibitors (TKIs) serve important roles as drugs in managing hematological diseases. In healthy B cells, the B cell receptor (BCR) activates a tyrosine kinase known as Syk, which then activates BTK, PI3K, PLC􏰃2 and protein kinase...
Resource Type:: Honors College Thesis

Part-Load Optimization of an Organic Rankine Cycle

Creator:: Ramsey, Owen
Abstract:: Waste-heat-recovery Organic Rankine Cycle (ORC) systems use excess heat from industrial processes to produce electrical power. In many cases, the temperatures and mass flow rates of these excess-heat streams vary significantly over time, causing the ORC to often operate far from its design point. In this study, a control strategy...
Resource Type:: Honors College Thesis
Full Text:: by Owen Ramsey A THESIS submitted to Oregon State University

For What it is Worth: Meditations on the Meaning of Life with Camus and Nozick

Creator:: Cherry, Owen E.
Abstract:: The meaning of life is an enduring philosophical question. This paper seeks to explore the thought of Albert Camus and Robert Nozick on the meaning of life and critically examine their contributions to philosophy. Camus begins with contemplating whether life is worth ending or worth living and concludes that only...
Resource Type:: Honors College Thesis
Full Text:: on the Meaning of Life with Camus and Nozick by Owen Cherry A THESIS submitted

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Creator:: Heppe, Kenan G.
Abstract:: F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control....
Resource Type:: Honors College Thesis
Full Text:: ]: Antibiotics. Accessed online at scribd.com/doc/7861440/Antibiotics [5]: Sheldon, A. T. Jr. Antibiotic

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:: Hobbs, Helen T.
Abstract:: As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...
Resource Type:: Honors College Thesis
Full Text:: ). 2. Ortman, J. T., Velkoff, V. A. & Hogan, H. Ortman, Jennifer M., Victoria A. Velkoff, and Howard

Visual Metaphors on Album Covers: An Analysis into Graphic Design's Effectiveness at Conveying Music Genres

Creator:: Le, Vivian T.
Abstract:: The rise of digital streaming has largely impacted the way the average listener consumes music. Consequentially, while the role of album art has evolved to meet the changes in music technology, it is hard to measure the effect of digital streaming on modern album art. This research seeks to determine...
Resource Type:: Honors College Thesis

Comparison of Joint Moments and Joint Contributions to Total Support Moment during the Propulsive Phase of a Triple Hop Task between Healthy and ACL Reconstructed Females

Creator:: Emma Gibbs
Abstract:: Recent research suggests that individuals might use compensatory movement patterns in their ACL-reconstructed (ACLR) limb when performing a triple hop (TH) to overcome quadriceps weakness. The purpose of this study was to determine if ACLR females exhibit differences in TH performance compared to previously uninjured females. Nineteen females with ACLR...
Resource Type:: Honors College Thesis
Full Text:: . REFERENCES Barfod, K. W., Feller, J. A., Hartwig, T., Devitt, B. M., & Webster, K. E. (2019). Knee extensor

ScholarsArchive@OSU

Rational design of ex vivo model of thrombosis

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Effects of Inhibitors against Syk-BTK-PI3K Signaling on Platelet Function

Part-Load Optimization of an Organic Rankine Cycle

For What it is Worth: Meditations on the Meaning of Life with Camus and Nozick

Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Visual Metaphors on Album Covers: An Analysis into Graphic Design's Effectiveness at Conveying Music Genres

Comparison of Joint Moments and Joint Contributions to Total Support Moment during the Propulsive Phase of a Triple Hop Task between Healthy and ACL Reconstructed Females

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