Index Catalog // ScholarsArchive@OSU

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

Creator:: Hall, Mark
Abstract:: Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
Resource Type:: Honors College Thesis
Full Text:: . Mark Hall, Author Acknowledgments I would like to thank Dr. Zili Zhang, Wenwei Zhong, and

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: 2013 C. Dong, G. Zhao, M. Zhong et al AR, C/EBPα, C/EBPδ, E2F4, EGR1, P300, FOS, FOXA2, FOXO1

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: 2013 C. Dong, G. Zhao, M. Zhong et al AR, C/EBPα, C/EBPδ, E2F4, EGR1, P300, FOS, FOXA2, FOXO1

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: . Future Microbiol. 2009;4(9):1151-65. PMCID: 2821804. 23. Goodwin B, Jones SA, Price RR, Watson MA

Biocuration of rice (Oryza sativa) transcription factor networks involved in abiotic stress response

Creator:: El-Husseini, Sarah
Abstract:: Rice (Oryza sativa) is a common crop found in various regions worldwide where it is considered a staple food. Though widespread, O. sativa plants' growth, development, and yield are affected by environmental/abiotic stresses including drought, salinity, flooding, cold, heat, etc. Particularly, salinity stress leads to dehydration, overwhelms potassium pumps, and...
Resource Type:: Honors College Thesis

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Creator:: Engstrom, Arek
Abstract:: The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...
Resource Type:: Honors College Thesis
Full Text:: exposure of such materials to all Engstrom 10 living matter (Ashby, Pan, & Zhong, 2014). Despite

Gold Nanoparticles as Thiophenol Detection Probes

Creator:: Pond, Emily
Abstract:: The development of simple, rapid, and sensitive methods for thiophenol detection is of great importance in various fields, including environmental monitoring and food quality. Here, we present a novel approach for the colorimetric detection of thiophenols using gold nanoparticles (AuNPs) as the sensing platform. AuNPs aggregate in the presence of...
Resource Type:: Honors College Thesis
Full Text:: (Millipore Milli-Q Advantage A10) from EMD Millipore (Burlington, MA, USA) and used for all solutions

Thermodynamic analysis of a magnesium carbonate thermochemistry and compressed air energy storage system

Creator:: Rebarchik, Eric R.
Abstract:: In this work, a hybrid thermochemistry compressed air energy storage (CAES) system is investigated. Following a review on chemical reactions investigated for use in thermochemical energy storage (TCES) systems, from these chemistries, the conversion of magnesium carbonate, MgCO3, to magnesium oxide, MgO, and carbon dioxide, CO2, was further analyzed for...
Resource Type:: Honors College Thesis
Full Text:: Buildings 2012, 55, 685-692. [3] Wang, X.; Yang, C.; Huang, M.; Ma, X. Off-design performances of gas

Regulation of the Metabolic Reprogramming of Schwannoma Cells by Nitrated Hsp90

Creator:: Bastian, Lydia P.
Abstract:: This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It...
Resource Type:: Honors College Thesis
Full Text:: Fisher Scientific, Waltham, MA, USA) for 4 minutes. An additional 8 mL SCM was added to neutralize

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: , Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van

ScholarsArchive@OSU

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Biocuration of rice (Oryza sativa) transcription factor networks involved in abiotic stress response

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Gold Nanoparticles as Thiophenol Detection Probes

Thermodynamic analysis of a magnesium carbonate thermochemistry and compressed air energy storage system

Regulation of the Metabolic Reprogramming of Schwannoma Cells by Nitrated Hsp90

The Role of Nrf2 in Brain Cellular Senescence

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