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Filtering by: Creator Sukhatme, Gaurav S. Remove constraint Creator: Sukhatme, Gaurav S. Peer Reviewed No Remove constraint Peer Reviewed: No Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
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    Dissertation
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    : ______________________________________________________ Gaurav Sahay Abstract Intracellular delivery of mRNA holds great potential for vaccine

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
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    Dissertation
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    Therapeutics Abstract approved: ______________________________________________________ Gaurav

  • Non-viral Vectors for Ocular Gene Delivery

    Creator:
    Herrera-Barerra, Marco, F.
    Abstract:
    Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
    Resource Type:
    Dissertation
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    Gaurav Sahay ABSTRACT Nucleic acid therapeutics has cemented itself as one of the most

  • Bacterial hydrophobicity : assessment techniques, applications and extension to colloids

    Creator:
    Saini, Gaurav
    Abstract:
    This research details laboratory assessment of bacterial hydrophobicity, variations in bacterial adhesion properties with growth and extended starvation as well as extension of this assay to colloidal hydrophobicity measurement. Hydrophobicity is an integral component of surface interactions and has been studied extensively for its role in a number of engineering...
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    Dissertation
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    ABSTRACT OF THE DISSERTATION OF Gaurav Saini for the degree of Doctor of Philosophy in Chemical

  • Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

    Creator:
    Bajaj, Gaurav
    Abstract:
    EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
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    Dissertation
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    ABSTRACT OF THE DISSERTATION OF Gaurav Bajaj for the degree of Doctor of Philosophy in Pharmacy

  • Learning to coordinate in sparse asymmetric multiagent systems

    Creator:
    Dixit, Gaurav
    Abstract:
    Multiagent learning offers a rich framework to address challenging real-world problems such as remote exploration and healthcare coordination, which require autonomous agents to express elaborate interactions. To be effective in such systems, agents must collectively reason about and pursue high-level, long-term, and possibly nebulous objectives while adapting their strategy to...
    Resource Type:
    Dissertation
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    AN ABSTRACT OF THE DISSERTATION OF Gaurav Dixit for the

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
    Resource Type:
    Dissertation
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    would like to thank all of my committee members, Drs. Adam Alani, Gaurav Sahay, Jung Kwon for their

  • Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

    Creator:
    Albarqi, Hassan Ahmad M.
    Abstract:
    Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
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    Dissertation
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    Alani, Gaurav Sahay, and Ling Jin for serving on my thesis committee and their guidance. Special

  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
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    Dissertation
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    , Dr. Gaurav Sahay, and Dr. Jerry Jaboin, thank you for always attending meetings ready to provide

  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
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    Dissertation
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    diagnosed ovarian cancer cases and usually but not always affects the younger women (early 20’s) [20