Genetic and environmental factors influence individual cancer risk. Mutations in DNA mismatch repair (MMR) genes increase colon cancer risk. Exposure to carcinogens, including the ubiquitous polycyclic aromatic hydrocarbons (PAHs), also is associated with increased cancer risk. To understand the combined effects of both environmental exposures and genetic risk, we investigated...
DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...
The Oregon Department of Energy has set up recommendations for agricultural crop and non-crop embargo zones following an accidental or purposeful radioactive release. Of special interest are the FDA’s Derived Intervention Levels (DIL) and the state’s exposure limit of 0.4µR/hr. At the Oregon State University Emergency Response Research and Support...
The relationships between zinc, iron, and phosphorus in sweet
corn were investigated under field and greenhouse conditions. The
soils used in this study (both acid and calcareous) were low in available
zinc and phosphorus.
The experiments received standard, uniform rates of nitrogen
potassium, magnesium, and sulphur. Corn was used as...
NCRP report No.160 states that medical exposure increased to nearly half of the total radiation exposure of the U.S. population from all sources in 2006 (NCRP 2009). Part of this increase in exposure is due to the rise in nuclear medicine procedures. With this observed growth in medical radionuclide usage,...