Urban areas currently cover a small fraction of Oregon’s landscape but will expand to accommodate an increasingly large proportion of the state’s growing population and economic activity. Residential developments on rural lands now cover more than twice the area occupied by Oregon’s urban developments and are growing rapidly. Oregon urban...
Breast cancer is the leading cancer in women with an estimated 13% of women in the United States developing a form of invasive breast cancer in her lifetime. The survival rate is estimated to be 85%, but the American Cancer Society estimates that early detection of breast cancer in the...
Monophyly of the gomphoid-phalloid clade was confirmed based on multigene phylogenetic analyses. Four major subclades (Hysterangiales, Geastrales, Gomphales and Phallales) were also demonstrated to be monophyletic. The interrelationships among the subclades were, however, not resolved, and alternative topologies could not be rejected statistically. Nonetheless, most analyses showed that the Hysterangiales...
While there are many ways to evaluate a user interface design, the user's mental workload and situation awareness (SA) are particularly important considerations in the supervisory control of safety-critical systems. Typically, operators of these systems must monitor high-volume, time-sensitive status information. Interface design for this domain can be challenging and...
This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
The advancement of artificial intelligence (AI) has led to transformative developments across multiple sectors, fostering innovation and redefining our interactions with technology. As AI matures and becomes integrated into society, it offers numerous opportunities to address global challenges and revolutionize a wide array of human endeavors. These advances are driven...
Engineered nanomaterials (ENMs) are small anthropogenic colloids with at least one length dimension <100 nanometers. Due to the nature of their use, ENMs are being increasingly released to the environment. Yet the environmental risks posed by ENMs are unknown due to a variety challenges, including limitations with detecting and quantifying...
Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...