Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
Ecologists must increasingly balance the need for accurate predictions about how ecosystems will be affected by climate change, against the fact that making such predictions at the ecosystem-level may be infeasible. Although information about responses of individual species to a changing environment is increasing, scaling such information to the community...
Stock assessments for many U.S. Pacific coast groundfish stocks are developed using the catch-at-age method known as Stock Synthesis. In this work a simulation package was developed and used to evaluate the sensitivity of the Stock Synthesis program. More specifically, the evaluation focused on the impacts of input data errors...
Rhizopogon is a large genus of ectomycorrhizal (EM) fungi that grows in association with host trees of the family Pinaceae. We have conducted a series of studies investigating the ecology and evolutionary biology of the EM symbiosis shared between R. subgenus Villosuli and trees of the genus Pseudotsuga. Two members...
Many home users nowadays use various smart devices to improve the efficiency and convenience of their home environments. Trigger-action platforms such as “If-This-Then-That” (IFTTT) enable end users to connect different smart devices and services using simple apps to control these devices and automate the tasks (e.g., if the camera detects...
Uranyl peroxide clusters are the newest family of polyoxometalates, discovered in 2015. Although this family is new, over 70 topologies have been reported. However, we lack the fundamental understanding of assembly mechanisms, particularly the role of the alkali countercations. Here, we use a wide range of solution and solid-state characterization...
Silicon photonics has become the most promising platform for future large-scale optical interconnect and optical computing systems due to its inherent CMOS compatibility, which brings exclusive advantages in bandwidth density, energy efficiency, and cost effectiveness. Parallel optical interconnects based on photonic integrated circuits (PICs) have the capacity to meet the...
The influence of increasing temperatures on human health has been widely established across multiple health disciplines. Short-term temperature changes are associated with an increased risk of hospitalization and death overall and in a variety of health conditions, such as cardiovascular disease. Even as humans can self-regulate heat stresses, the elderly,...
Powder injection molding (PIM) is a net fabrication technique that combines the
complex shape-forming ability of plastic injection molding, the precision of die-casting,
and the material selection flexibility of powder metallurgy. For this
study, the design issues related to PIM for fabrication of thin-walled high-aspect
ratio geometries were investigated. These...