Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C
derivative in vivo, are known chemopreventive agents available as dietary supplements.
I3C was found to suppress or enhance tumors in several animal models.
Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism
effectively blocking initiation. However, mechanisms for enhancement...
Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage.
The aim of this study...
Pesticides are among the most pervasive environmental contaminants and they are an important potential risk for human health. Agricultural workers are constantly exposed to pesticide spray, drift and residues in the soil and foliage. Many agricultural pesticides are readily absorbed by the body, through contact with the skin, the respiratory...
Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Vacuum ultraviolet absorption spectra of 13 model sugar compounds
were measured in the energy range of 50 to 80 kK. The model
sugars included three simple alcohols, four simple ethers, four cyclic
alcohol-ether compounds, and two dioxanes. All spectra show
transition bands in the energy region 50 to 65 kK....
There has been concern voiced for a number of years about the problem of program plagiarism. A number of SIGCSE Bulletin articles have discussed the issue. However, it is not at all clear as to what behavior we are actually referring, nor to what extent it is occurring. How do...
The circular dichroism spectra of amylose, the maltose
oligomers, cellobiose, and the cycloamyloses are measured in
aqueous solution to 1640 A. Two bands are found in this region. The
long wavelength band is assigned to the ether chromophores; the short
wavelength band is assigned to the hydroxyls and further ether...