Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
This ethnographic research examines socioeconomic vulnerabilities to resettlement from a large hydropower dam and agricultural commodification in a Tibetan village in Yunnan Province, Southwest China. After providing an initial background on the dynamics of the research region and hydrodevelopment on its rivers, the research framework of examining vulnerability through a...
Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes.
Abstract for...
Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Ecological domains seeking to understand the environment and the behavior of species have received little attention in machine learning (ML), despite the fact that environmental changes have a significant impact on humans as well as ecosystems. Some ecological problems can be formulated similarly to other common ML applications, but there...
Silicon photonics has become the most promising platform for future large-scale optical interconnect and optical computing systems due to its inherent CMOS compatibility, which brings exclusive advantages in bandwidth density, energy efficiency, and cost effectiveness. Parallel optical interconnects based on photonic integrated circuits (PICs) have the capacity to meet the...
Widespread installation of renewable energy sources, such as wind and solar, has been delayed by the lack of suitable stationary energy storage solutions. Current large-scale technologies, such as pumped hydro and compressed air, are geographically restricted. This is where electrochemical energy storage - batteries or hybrid capacitors can play a...
Nonthermal plasmas generate high concentrations of excited species that can simultaneously exist at high energy and far from thermodynamic equilibrium, making them useful tools in chemistry and engineering. Microplasmas, roughly defined as plasmas that are generated within sub-millimeter dimensions, provide enhanced stability, improved excited species density, increased nonequilibrium properties, higher...
Advances in low-power digital integration and microelectro-mechanical systems (MEMS) have paved the way for micro-sensors. These sensors are equipped with data processing capabilities along with sensory circuits. Sensor data are processed on these individual sensors and transmitted to the target (sink). Lowcost integration and small sizes of these sensors have...
Within the past several years the technology of high-throughput sequencing has transformed the study of biology by offering unprecedented access to life's fundamental building block, DNA. With this transformation's potential a host of brand-new challenges have emerged, many of which lend themselves to being solved through computational methods. From de...