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  • Impact of Unfolded Protein Response, USP14, and NEDD8 Inhibitors Upon Antigen Presentation in SaI/Ak and 4T1 Tumor Cell Lines

    Creator:
    Godil, Jamila A.
    Abstract:
    Antigen presentation is a mechanism used by cells to present peptides on the cell surface. Peptides, derived from both viral or self-proteins are presented on the cell surface by MHC Class I molecules to be recognized and detected by cytotoxic T cells. T cells comprise the defense system to protect...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Brian Dolan Antigen presentation is a mechanism used by cells to present peptides on the

  • MHC class I molecules and Antigen Presentation

    Creator:
    Salem, Fares B.
    Abstract:
    Research in Dolan lab focuses primarily on the adaptive immune system and ways it can be better utilized to eliminate infected or transformed cells. Research focuses on the major histocompatibility (MHC) class I antigen presentation pathway, which plays an important role in alerting the immune system of the presence of...
    Resource Type:
    Presentation
    Full Text:
    ladder, Shld-L construct, EtOH-L, Shld-K, and finally EtOH-K Acknowledgements •Brian Dolan •Ryan

  • Cytokine expression in Danio rerio (zebrafish) in response to TLR-7 agonist - Imiquimod

    Creator:
    Paternostro, Kevin Alan
    Abstract:
    Utilizing Danio rerio (zebrafish) as a model organism has gained popularity recently, however a lack of research into their immune response pathways had led to the discovery of subclinical infections, and has potentially confounded results. We conducted a study to determine the cytokine expression from TLR activation in order to...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ______________________________________________________ Brian Dolan Utilizing Danio rerio (zebrafish) as a model organism has gained popularity

  • Crossing Boundaries during Stress Responses: Antigen Presentation by Adaptive and Innate MHC Class I Molecules

    Creator:
    Nagamine, Brandy S.
    Abstract:
    The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________ Brian P. Dolan The immune system is a complex network of cellular processes working

  • Non-Canonical Nedd8 Conjugation Mediated Targeted Protein Degradation and Direct Antigen Presentation

    Creator:
    Vijayasimha, Kartikeya
    Abstract:
    While the role of ubiquitin in protein degradation is well established, the role of other ubiquitin-like proteins (UBLs) in protein degradation is less clear. Neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) is the UBL with the highest level of amino acid identity when compared to ubiquitin. Here we...
    Resource Type:
    Dissertation
    Full Text:
    Presentation. Abstract approved: ______________________________________________________ Brian P. Dolan

  • Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

    Creator:
    VanderHoek, Eden N.
    Abstract:
    Human epidermal growth factor receptor 2 (HER2), a member of the receptor tyrosine kinase (RTK) family, is frequently dysregulated in a variety of cancers. Overexpression of the receptor leads to increased cell proliferation and resistance to cell death due to downstream signaling effects. Proteasomal degradation of HER2 results in the...
    Resource Type:
    Honors College Thesis
    Full Text:
    Soheila Kazemi _____________________________________________________ Brian Dolan Human

  • Investigating variation in immunity and infection risk in wild ungulates

    Creator:
    Dugovich, Brian S.
    Abstract:
    In the midst of the sixth mass extinction, understanding wildlife disease spillover is critical to maintaining protected wildlife areas. Studying ecoimmunology and wildlife disease ecology helps to understand immune and disease traits in an ecological context, which is invaluable in preventing pathogen spillover between livestock and wildlife. To investigate this...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Anna E. Jolles Brian P. Dolan In the midst of the sixth mass extinction