All attempted synthesis of perfluoroalkyl boron bonded groups
have resulted in the formation of boron-fluorine bonds from the
probable decomposition by α-fluorine transfer. The substance alkali
metal di-n- butylborate (I) has been identified as the potassium derivative
by its reaction with di-n-butylboron chloride and isolation of
potassium chloride. The reaction...
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Thioredoxin reductase specifically catalyzes the NADPH-dependent reduction of thioredoxin. Thioredoxin provides a source of electrons for disulfide reduction in various cellular processes. Reduction of disulfides within the cell can be accomplished by...
Aerobic organisms have evolved many sensory mechanisms that allow
response to oxidants in the environment. One area of interest is the relationship
between the activity of the tumor suppressor protein p53 and the redox state of
thioredoxin. Human p53 activity is severely compromised in budding yeast lacking
thioredoxin reductase. Evidence...
In budding yeast, many of the genes that encode enzymes required for DNA precursor synthesis (MCB genes) are expressed under cell cycle control in late G1/S. The relationship between MCB gene expression, dNTP synthesis and DNA synthesis was investigated by using α factor-synchronized Saccharomyces cerevisiae. The levels of all four...
Replication associated protein and enzyme activity levels increase as cells enter
S-phase of the cell cycle and diminish as cells leave S-phase. Accordingly, replication
associated functions decrease as myoblasts withdraw from the cell cycle to terminally
differentiate. In an effort to understand signals effecting growth associated expression
of genes, the...
Gaps in the forest canopy allow more light to reach the understory. Since
light in the understory is heterogeneous, understanding the physiological
processes in gaps and non-gaps will improve estimates of carbon balance. This
research outlines an approach for defining carbon balance for Salal (Gaultheria
shallon Pursh.), a dominant understory...
Examination of a proposed reaction scheme to prepare bicyclo-(2.2.0)hexan-1-ol produced the first known condensation of an
enamine with its carbonyl precursor. Hydrolysis of the resulting
dienamine gave an unusual conjugated cyclobutenone in which the
double bond is exocyclic. Characterization and reactions of the
cyclobutenone were successfully carried out.
