Index Catalog // ScholarsArchive@OSU

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:: Breysse, Daniel H.
Abstract:: Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Daniel Breysse for

Factors affecting within-season and between-season breeding dispersal of burrowing owls in California

Creator:: Catlin, Daniel H.
Abstract:: Dispersal is integral to our understanding of the life history and population biology of many vertebrates, but difficulties in detecting long distance movements have complicated its study. Moreover, studies of factors affecting dispersal are often unable to determine the relative contributions of variables such as nesting success, mate fidelity, and...
Resource Type:: Masters Thesis

Alteration in levels and synthesis of proteins in trout hepatocytes due to dietary cyclopropenoid fatty acid[s]

Creator:: Perdew, Gary H.
Abstract:: Cyclopropenoid fatty acids (CPFA) are unique compounds that contain a highly strained and reactive cyclopropene ring structure. These compounds have been shown to cause a number of toxic effects in a variety of animals. Rainbow trout (Salmo gairdneri) have proven to be particularly sensitive to CPFA. Studies have revealed that...
Resource Type:: Dissertation
Full Text:: , 1984 Typed by Sue Hecht for Gary H. Perdew ACKNOWLEDGEMENTS I wish to thank Drs. Daniel P

Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora

Creator:: Halsey, Kimberly H.
Abstract:: Pseudomonas butanovora, Mycobacterium vaccae, and Nocardioides sp. CF8 utilize distinctly different butane monooxygenases (BMOs) to initiate degradation of recalcitrant chlorinated ethenes (CEs) that pollute aquifers and soils. BMO-dependent degradation of CEs such as trichloroethylene (TCE) can lead to cellular toxicities. The type and severity of TCE transformation-dependent damage can have...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Kimberly H. Halsey for the degree of Doctor of Philosophy in Molecular and Cellular

Identification and characterization of a heat stable protease in arrowtooth flounder (Atheresthes stomias) and methods of inhibition in surimi

Creator:: Wasson, Diana H.
Abstract:: A heat stable protease was identified as the cause of textural degradation in cooked arrowtooth flounder (Atheresthes stomias) muscle. Maximum proteolytic activity in the fish muscle was observed between 55°C and 60°C and myosin heavy chain appeared to be the primary substrate for the enzyme. Degradation of this myofibrillar protein...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Diana H. Was son for the

Numerical assessment of steel plate shear wall with coupling (SPSW-WC) system design procedure

Creator:: Li, Wennan
Abstract:: The Steel Plate Shear Wall (SPSW) system, is an innovative seismic lateral force resistant system, which has experienced increased use over the last three decades. The SPSW system is composed of boundary elements which anchor web plates that develop diagonal tension fields. A number of SPSW buildings have been built...
Resource Type:: Masters Thesis
Full Text:: Steel Plate Shear Wall with Coupling (SPSW-WC) System Design Procedure Abstract approved: Daniel

Upgrading of a model compound of bio-oil using carbon monoxide in high temperature water

Creator:: Phipps, Ezra Daniel
Abstract:: Meeting the energy demands of the future is one of the most important challenges facing the engineering community today. An example of this problem is transportation fuels. Most of the current transportation fuels are composed of petroleum hydrocarbons. Finding a viable alternative is important given the potential scarcity of these...
Resource Type:: Masters Thesis
Full Text:: Ezra Daniel Phipps for the degree of Master of Science in Chemical Engineering presented on May 29

Hydroperoxide formation in the radiolysis of aqueous DNA and the pyrimidine bases

Creator:: Schwiebert, Maris Carol
Abstract:: The formation of cytosine hydroperoxide was detected in aqueous cytosine solutions irradiated with Co-60 γ-rays at pH 2. The nucleotide of cytosine, cytidylic acid, forms a hydroperoxide which was detected in neutral solution. The stability of the hydroperoxides of cytosine, thymine, and their nucleotides was found to be a function...
Resource Type:: Masters Thesis
Full Text:: Dependence of TO H formation in 0. 1% DNA upon dose. 57 12 Dependence of CO H formation in 0. 1 percent DNA

The impact of child-centered play therapy on anxiety levels in pre-neurosurgical pediatric patients

Creator:: Lerwick, Julie L.
Abstract:: The prevalence of childhood illness requiring hospitalization establishes the need for implementation of an applied intervention to decrease levels of hospitalization-induced anxiety in pediatric patients. In addition to anxiety, levels of perceived trauma have also been linked to pre-operative pediatric patients. Child-Centered Play Therapy (CCPT) within the medical setting has...
Resource Type:: Dissertation
Full Text:: : ___________________________________________________________________ Daniel Stroud The prevalence of childhood illness requiring hospitalization establishes

Large-scale laboratory observations of wave forces on a highway bridge superstructure

Creator:: Bradner, Christopher
Abstract:: The experimental setup and data are presented for a laboratory experiment conducted to examine realistic wave forcing on a highway bridge superstructure. The experiments measure wave conditions along with the resulting forces, pressures, and structural response of a 1:5 scale, reinforced concrete model of a typical section of the I-10...
Resource Type:: Masters Thesis
Full Text:: Bridge Superstructure Abstract approved: Daniel T. Cox The experimental setup and data are

ScholarsArchive@OSU

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Factors affecting within-season and between-season breeding dispersal of burrowing owls in California

Alteration in levels and synthesis of proteins in trout hepatocytes due to dietary cyclopropenoid fatty acid[s]

Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora

Identification and characterization of a heat stable protease in arrowtooth flounder (Atheresthes stomias) and methods of inhibition in surimi

Numerical assessment of steel plate shear wall with coupling (SPSW-WC) system design procedure

Upgrading of a model compound of bio-oil using carbon monoxide in high temperature water

Hydroperoxide formation in the radiolysis of aqueous DNA and the pyrimidine bases

The impact of child-centered play therapy on anxiety levels in pre-neurosurgical pediatric patients

Large-scale laboratory observations of wave forces on a highway bridge superstructure

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