Index Catalog // ScholarsArchive@OSU

Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

Creator:: Justen, Savannah F.
Abstract:: Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by the tox operon in Burkholderia glumae, in which the encoded protein, ToxD, was previously characterized as essential...
Resource Type:: Honors College Thesis
Full Text:: Philmus, Mentor, representing the College of Pharmacy Jane Ishmael, Committee Member, representing the

Role of Pitx2 in regulation of cardiac remodelling

Creator:: Bhatt, Shachi
Abstract:: Background: Heart morphogenesis involves chamber formation followed by septation. Septation is the remodeling of the heart from a single channel peristaltic pump to a two channel pump with one-way valves. Several transcription factors have been implicated in the development of congenital cardiac defects. The paired-like homeodomain transcription factor Pitx2 has...
Resource Type:: Masters Thesis
Full Text:: committee members, Dr. Jane Ishmael and Dr. Lawrence Curtis. I would like to thank Dr. George Porter Jr

Health risk of bathing in Southern California coastal waters

Creator:: Brinks, Mitchell V.
Abstract:: Bathers exposed to microbiological contamination in coastal waters have an excess risk of gastrointestinal and respiratory illness. The disease burden associated with this risk may be considerable in Southern California, where 50 million annual beach visitors recreate in coastal waters that receive billions of gallons of polluted discharges from nearby...
Resource Type:: Masters Thesis

Studies on the ecological functions of the antidiabetic drugs acarbose

Creator:: Tanoeyadi, Samuel
Abstract:: Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
Resource Type:: Masters Thesis
Full Text:: . Jane Ishmael, and Dr. Molly Megraw, for all of their time, expertise, and readiness in serving my

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation
Full Text:: members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: histology slides. I thank my committee members, Charles Toombs, Jane Ishmael and Victor Hsu for their

Investigation of Procyanidins Used in Botanical Dietary Supplements

Creator:: Rue, Emily A.
Abstract:: Polyphenolic compounds found in foods such as fruits, vegetables, legumes, nuts and grains, are an integral part of the human diet. Within polyphenols, proanthocyanidins are referred to as condensed tannins and encompass procyanidins, propelargonidins and prodelphinidins. Among these, procyanidins are the largest group. Recent interest in these compounds is related...
Resource Type:: Dissertation
Full Text:: Drs. Taifo Mahmud, Jane Ishmael, Robert McGorrin, and Jung Kwon for their guidance and intellectual

Understanding the Influence of Perceived Usefulness of Evidence Based Interventions and Employee Morale on the Relationship between Participatory Internal Communication and Program Fidelity

Creator:: Osibanjo, Oyindamola I.
Abstract:: Translation of efficacious programs into real-world settings is an important step in ensuring improved public health outcomes. Yet, the process of translating evidence-based interventions (EBIs) according to fidelity is fraught with challenges. Organizational factors, specifically organizational communication, have been shown to influence translation processes. To date, there is limited research...
Resource Type:: Dissertation
Full Text:: committee members including Drs. Peggy Dolcini, Sheryl Thorburn, Jonathan Garcia, and Jane Ishmael. The

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Creator:: Vyshenska, Dariia
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
Resource Type:: Dissertation
Full Text:: grateful to my committee members, Stephen Ramsey, Jane Ishmael, and Kathy Magnusson for their vital

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

Creator:: Kaweesa, Elizabeth Namagoba
Abstract:: Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Resource Type:: Masters Thesis
Full Text:: Blakemore, Dr. Jane Ishmael, Dr. Kerry McPhail, Dr. Siva Kolluri and Dr. Taifo Mahmud for their insight

ScholarsArchive@OSU

Aiding Plants and Humans by Targeting Virulence Strategies: Investigation of key protein residues involved in toxoflavin production

Role of Pitx2 in regulation of cardiac remodelling

Health risk of bathing in Southern California coastal waters

Studies on the ecological functions of the antidiabetic drugs acarbose

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Investigation of Procyanidins Used in Botanical Dietary Supplements

Understanding the Influence of Perceived Usefulness of Evidence Based Interventions and Employee Morale on the Relationship between Participatory Internal Communication and Program Fidelity

Identification of Cervical Cancer Key Regulators using Network Biology Approach

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

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