The state of the knowledge for fault behavior in the northwest Himalaya and California varies dramatically. In the Pakistan and Kashmir Himalaya, few data constrain the role that individual active faults play in accommodating Indo-Eurasian convergence and the relative earthquake hazard across the region. By contrast, the San Andreas fault...
Wheat stripe rust (WSR), also called yellow rust of wheat (Tricitum spp.), causal agent Puccinia striiformis f.sp. tritici (Pst), is a foliar disease of major economic importance on wheat, especially grown in temperate locations. WSR causes major losses of wheat yield, estimated at nearly $ 1 billion per year, and...
It has long been observed that stress can increase our
susceptibility to infectious diseases and cancers. Recent
experimental evidence suggests that this increased susceptibility is
due to suppression of immunity. A variety of neuroendocrine products
are released during periods of stress, and a large number of these
are now known...
Most studies of plant disease epidemiology have focused on epidemics in host
populations composed of a single genotype. But crop plant diversity can be a useful
means of improving the deployment of resistance genes. In a series of experiments with wheat stripe rust and potato late blight, we studied factors...
Primary disease gradients of wheat stripe rust, caused by the aerially dispersed fungal pathogen Puccinia striformis, were measured in Madras and Hermiston, OR in the springs of 2002 and 2003. Disease foci were created by inoculating a 1.52m x 1.52m area in each of three replicate field plots (6.1m wide...
Mycosphaerella graminicola (anamorph Septoria tritici) causes Septoria tritici blotch, a globally important disease of winter wheat. Resistance and pathogenicity generally vary quantitatively. The pathogen reproduces both sexually and asexually, and the pathogen population is highly genetically variable. Several unresolved questions about the epidemiology of this pathosystem are addressed by this...
At the intersection of basic science research and clinical relevance, cancer metastasis and cell invasion is a multifaceted problem that has been investigated for the past several decades. Importantly, cancer cell plasticity, the ability of a single cell to change its phenotype without genetic mutations in response to environmental cues,...
The public controversy over possible health hazards from radioactive fallout from atomic bomb testing began in 1954, shortly after a thermonuclear test by the United States spread fallout world wide. In the dissertation, I address two of the fundamental questions of the fallout controversy: Was there a threshold of radiation...
A study consisting of three parts was undertaken to investigate how variation in species interactions, population genetic structure, epidemiological parameters, and plant breeding system may influence the ecology and biological control of an apomictic invasive plant, Chondrilla juncea (Asteraceae). Interactions between natural enemy species may modify their net effect on...
With the rise of resistant bacterial pathogens, currently prescribed antibiotics are rendered useless. In recent years, marine natural products (MNPs) have emerged as novel sources for drug leads. The ocean is a complex environment where marine animals cohabitate with many, and sometimes harmful microorganisms and viruses, but resist infections. Developed...