DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Many failures of interpersonal communication and coordination in the aircraft cockpit have been found to occur as a result of poor management of flightdeck 'resources'. Crew Resource Management (CRM) is a concept that has evolved within the aviation community to specifically address this issue of resource management. The concept of...
The thesis area covers 165 square miles including the greater
part of the northeastern quarter of the Mitchell quadrangle in north-central Oregon. The three stratigraphic units exposed in the area
consist of a variety of Tertiary volcanic rocks including the Clarno
Formation, the John Day Formation, and the Columbia River...
Take-all root rot (caused by Gaeumannomyces graminis var.
tritici, Ggt) is one of the major diseases limiting winter wheat
yields in western Oregon. Losses caused by take-all (TA) can be
significantly reduced through crop management and fertilization
practices.
Results from field experiments in western Oregon show that the
use of...
The two most economically important plant pathogens in the Pseudoperonospora (Peronosporaceae) genus are P. cubensis, causal agent of cucurbit downy mildew, and P. humuli, causal agent of hop downy mildew. These organisms have been shown to be very closely related phylogenetically and morphologically. In 2005, researchers in Korea proposed that...
Composites often are able to carry more load after damage due to the structure of laminates. In addition, damage can be difficult to detect in composites compared to homogeneous materials. Understanding the behavior of composite material after damage is vital for composite structural design. Currently, experimental methods exist for classifying...