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  • Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora

    Creator:
    Halsey, Kimberly H.
    Abstract:
    Pseudomonas butanovora, Mycobacterium vaccae, and Nocardioides sp. CF8 utilize distinctly different butane monooxygenases (BMOs) to initiate degradation of recalcitrant chlorinated ethenes (CEs) that pollute aquifers and soils. BMO-dependent degradation of CEs such as trichloroethylene (TCE) can lead to cellular toxicities. The type and severity of TCE transformation-dependent damage can have...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Major Professor, representing Molecular and Cellular Biology

  • Genetic dissection of Victoria blight disease susceptibility in Arabidopsis thaliana

    Creator:
    Sweat, Teresa A.
    Abstract:
    The fungus Cochliobolus victoriae causes Victoria blight of oats and Arabidopsis and is pathogenic due to its production of a compound called victorin, which induces programmed cell death in sensitive plants. Victorin sensitivity in Arabidopsis is conferred by the dominant gene LOCUS ORCHESTRATING VICTORIN EFFECTS1 (LOV1), which encodes a coiled-coil-nucleotide...
    Resource Type:
    Dissertation
    Full Text:
    OF Teresa A. Sweat for the degree of Doctor of Philosophy in Molecular and Cellular Biology

  • Endogenous and antiviral RNA silencing pathways in Arabidopsis

    Creator:
    Chapman, Elisabeth J.
    Abstract:
    RNA silencing pathways are required for a wide variety of processes in most eucaryotes. In plants, small-interfering RNA (siRNA) arising from transposons and other repetitive sequences is associated with heterochromatin formation and maintenance. MicroRNAs and trans-acting siRNAs encoded at discrete loci function as negative regulators of gene expression by triggering...
    Resource Type:
    Dissertation
    Full Text:
    Molecular and Cellular Biology presented on April 24, 2007. Title: Endogenous and Antiviral RNA

  • Mechanisms for the interaction of environmental mycobacteria with host cells

    Creator:
    Harriff, Melanie J.
    Abstract:
    Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
    Resource Type:
    Dissertation
    Full Text:
    Biology Co-Major Professor, representing Molecular and Cellular Biology Director of the

  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
    Full Text:
    , representing Molecular and Cellular Biology Chair of the Molecular and Cellular Biology Program

  • Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

    Creator:
    Tripp, H. James
    Abstract:
    To identify factors limiting 'Candidatus Pelagibacter ubique' maximum cell density and growth rate in pure culture on seawater, the genome sequence of 'Cand. P. ubique' was analyzed, culturing experiments with organic and inorganic nutrient additions were made, and radiotracer uptake experiments were performed. The genome was sequenced, custom data mining...
    Resource Type:
    Dissertation
    Full Text:
    Molecular and Cellular Biology presented on June 7, 2007. Title: Genomic-Assisted Determination of the

  • Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

    Creator:
    Zhang, Yong
    Abstract:
    Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Yong Zhang for the degree of Doctor of Philosophy in Molecular and Cellular Biology

  • Characterization of acid sensing ion channel (ASIC) in mouse olfactory bulb

    Creator:
    Kratzer, Eric Martin
    Abstract:
    This study examined the role of acid- sensing ion channels (ASICs) in interneuron synaptic modulation. ASICS are ultra fine discriminators of acidic conditions in the neuronal microenvironment. Each ASIC subunit isoform has innate, subtly different electrophysiological properties and tissue distributions. Structurally, ASICs may form homo- or heteromeric channels, yielding combinatorial...
    Resource Type:
    Dissertation
    Full Text:
    : Major Professor, representing Molecular and Cellular Biology Director of the Molecular and

  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
    Resource Type:
    Dissertation
    Full Text:
    : _______________________________________________________________________ Major Professor, representing Molecular and Cellular Biology

  • An emerging role for the exocyst : plant morphogenesis

    Creator:
    Cole, Rex A.
    Abstract:
    Plants develop a vast array of cell shapes and sizes by selectively modifying their surrounding cell walls to expand in some regions and not in others. This process of morphogenesis requires the delivery of secretory vesicles to specific locations at the cell periphery, where exocytosis adds new membrane and proteins...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Rex A. Cole for the degree of Doctor of Philosophy in Molecular and Cellular Biology