Index Catalog // ScholarsArchive@OSU

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

Creator:: Marley, Kevin, Gullaba, Justine, Seguin, Bernard, Gelberg, Howard B., and Helfand, Stuart C.
Abstract:: BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
Resource Type:: Article
Full Text:: , Bernard Seguin2, Howard B. Gelberg and Stuart C. Helfand Department of Clinical Sciences Oregon State

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Creator:: Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard
Abstract:: Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Resource Type:: Article
Full Text:: osteosarcoma in vitro Kevin Marley1, Stuart C Helfand1, Wade A Edris1,4, John E Mata2, Alix I Gitelman3, Jan

Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro

Creator:: Milovancev, Milan, Helfand, Stuart C., Marley, Kevin, Goodall, Cheri P., Löhr, Christiane V., and Bracha, Shay
Abstract:: Background: Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
Resource Type:: Article
Full Text:: *, Stuart C. Helfand1, Kevin Marley1, Cheri P. Goodall1, Christiane V. Löhr2 and Shay Bracha1 Abstract

Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Creator:: Marley, Kevin, Helfand, Stuart C., Simpson, Jennifer, Mata, John E., Tracewell, William G., Brownlee, Lisa, Bracha, Shay, and Séguin, Bernard
Abstract:: Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....
Resource Type:: Article
Full Text:: the safety of taurolidine for dogs with osteosarcoma Kevin Marley1, Stuart C Helfand1, Jennifer

Does Temperature-Mediated Reproductive Success Drive the Direction of Species Displacement in Two Invasive Species of Leafminer Fly?

Creator:: Wang, Haihong, Reitz, Stuart R., Xiang, Juncheng, Smagghe, Guy, and Lei, Zhongren
Abstract:: Liriomyza sativae and L. trifolii (Diptera: Agromyzidae) are two highly invasive species of leafmining flies, which have become established as pests of horticultural crops throughout the world. In certain regions where both species have been introduced, L. sativae has displaced L. trifolii, whereas the opposite has occurred in other regions....
Resource Type:: Article
Full Text:: ? Haihong Wang1, Stuart R. Reitz2, Juncheng Xiang1, Guy Smagghe3, Zhongren Lei1* 1 State Key Laboratory for

Frankliniella occidentalis (Pergande) integrated pest management programs for fruiting vegetables in Florida

Creator:: Demirozer, Ozan, Tyler-Julian, Kara, Funderburk, Joe, Leppla, Norm, and Reitz, Stuart
Abstract:: BACKGROUND: The spread of the western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), resulted in the worldwide destabilization of established integrated pest management programs for many crops. Efforts to control the pest and the thrips-vectored tospoviruses with calendar applications of broad-spectrum insecticides have been unsuccessful. The result has been a...
Resource Type:: Article
Full Text:: and Stuart Reitzd,e Abstract BACKGROUND: The spread of the western flower thrips, Frankliniella

Effects of hypoxia on habitat quality of pelagic planktivorous fishes in the northern Gulf of Mexico

Creator:: Zhang, Hongyan, Mason, Doran M., Stow, Craig A., Adamack, Aaron T., Brandt, Stephen B., Zhang, Xinsheng, Kimmel, David G., Roman, Michael R., Boicourt, William C., and Ludsin, Stuart A.
Abstract:: To evaluate the impact of hypoxia (< 2 mg O₂ l⁻¹) on habitat quality of pelagic prey fishes in the northern Gulf of Mexico, we used a spatially explicit, bioenergetics-based growth rate potential (GRP) model to develop indices of habitat quality. Our focus was on the pelagic bay anchovy Anchoa...
Resource Type:: Article
Full Text:: , David G. Kimmel6, Michael R. Roman7, William C. Boicourt7, Stuart A. Ludsin8 1Cooperative Institute

Prescribed fire effects on resource selection by cattle in mesic sagebrush steppe. Part 1: Spring grazing

Creator:: Clark, Patrick E., Lee, Jaechoul, Ko, Kyungduk, Nielson, Ryan M., Johnson, Douglas E., Ganskopp, David C., Chigbrow, Joe, Pierson, Fredrick B., and Hardegree, Stuart P.
Abstract:: Prescribed fire is commonly applied world-wide as a tool for enhancing habitats and altering resource-selection patterns of grazing animals. A scientific basis for this practice has been established in some ecosystems but its efficacy has not been rigorously evaluated on mesic sagebrush steppe. Beginning in 2003, resource-selection patterns of beef...
Resource Type:: Article
Full Text:: , Douglas E. Johnson d, David C. Ganskopp e, Joe Chigbrow f, Fredrick B. Pierson a, Stuart P. Hardegree a

Closely-related taxa influence woody species discrimination via DNA barcoding: evidence from global forest dynamics plots

Creator:: Pei, Nancai, Erickson, David L., Chen, Bufeng, Jones, Frank A., Ge, Xuejun, Mi, Xiangcheng, Swenson, Nathan G., Zhang, Jin-Long, Huang, Chun-Lin, Ye, Wanhui, Hao, Zhanqing, Hsieh, Chang-Fu, Lum, Shawn, Bourg, Norman A., Parker, John D., Zimmerman, Jess K., McShea, William J., Lopez, Ida C., Sun, I-Fang, Davies, Stuart J., Ma, Keping, and Kress, John
Abstract:: To determine how well DNA barcodes from the chloroplast region perform in forest dynamics plots (FDPs) from global CTFS-ForestGEO network, we analyzed DNA barcoding sequences of 1277 plant species from a wide phylogenetic range (3 FDPs in tropics, 5 in subtropics and 5 in temperate zone) and compared the rates...
Resource Type:: Article

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

Creator:: Das, Partha Pratim, Hendrix, David A., Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Kellis, Manolis, Hochedlinger, Konrad, Kim, Jonghwan, and Orkin, Stuart H.
Abstract:: Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
Resource Type:: Article

ScholarsArchive@OSU

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro

Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Does Temperature-Mediated Reproductive Success Drive the Direction of Species Displacement in Two Invasive Species of Leafminer Fly?

Frankliniella occidentalis (Pergande) integrated pest management programs for fruiting vegetables in Florida

Effects of hypoxia on habitat quality of pelagic planktivorous fishes in the northern Gulf of Mexico

Prescribed fire effects on resource selection by cattle in mesic sagebrush steppe. Part 1: Spring grazing

Closely-related taxa influence woody species discrimination via DNA barcoding: evidence from global forest dynamics plots

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

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