Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically based pharmacokinetic (PBPK) modeling efforts for PAHs have so far been limited to naphthalene, plus simpler PK models for pyrene, nitropyrene, and benzo[a]pyrene (B[a]P). The dearth of...
The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. DBC (4 nmol) was most potent, reaching 100% tumor incidence with a shorter latency...
Our objective was to identify the biological response and the cross-talk between liver and mammary tissue after intramammary infection (IMI) with Escherichia coli (E. coli) using RNAseq technology. Sixteen cows were inoculated with live E. coli into one mammary quarter at ~4–6 weeks in lactation. For all cows, biopsies were...
A model was developed to predict the severity of dwarf mistletoe (Arceuthobium tsugense (Rosendahl) G.N. Jones) in western hemlock trees (Tsuga heterophylla (Raf.) Sarg.) that developed within forests of Southeast Alaska that experienced near-catastrophic windthrow in the late 1800s. The model suggests that the degree of dwarf mistletoe severity on...
We form a new ‘blended’ data set of sea level anomaly (SLA) fields by combining gridded daily fields derived from altimeter data with coastal tide gauge data. Within approximately 55–70 km of the coast, the altimeter data are discarded and replaced by a linear interpolation between the tide gauge and remaining...
Peroxiredoxins (Prxs) were not recognized as a family of enzymes until the 1990s but are now known to be the dominant peroxidases in most organisms. Here, the history and fundamental properties of peroxiredoxins are briefly reviewed, with a special focus on describing how an exquisitely tunable balance between fully folded...
Lagrangian particle-tracking models (LPTMs) were used to identify sources, destinations, and transport pathways of particles (plankton). The LPTM simulations were forced using stored fields from the Spectral Element Ocean Model simulation for a coastal upwelling system having idealized geometry, bathymetry, and simple wind forcing. Forward-in-time-trajectory (FITT) simulations are common in...
Velocity time series are used to study cross-shelf circulation on the northern California shelf and to examine classical ideas of locally wind-forced cross-shelf circulation. A simple linear two-dimensional model of cross-shelf transport is compared to estimates of cross-shelf transport in the near surface, interior, and near bottom. In winter, when...