Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...
Since nucleic acids were first extracted directly from the environment and sequenced, metagenomics has grown to one of the most data-rich and pervasive techniques for understanding the taxonomic and functional diversity of microbial communities. In the last decade, cheaper sequencing has democratized the application of metagenomics and generated billions of...
Mountain pine beetle, Dendroctonus ponderosae Hopkins, is a primary agent of forest disturbance in western North America. Episodic outbreaks occur at the convergence
of favorable forest age and size class structure and climate patterns. Recent outbreaks have exceeded the historic range of variability of D. ponderosae-caused tree
mortality affecting ecosystem...
Models of magnetic and gravity anomalies along two E-W transects offshore central Oregon, one of which is coincident with a detailed velocity model, provide quantitative limits on the structure of the subducting oceanic crust and the crystalline backstop. The models indicate that the backstop-forming western edge of the Siletz terrane,...
Includes 1922 Summer School Graduates.
In the following pages the information, so far as it has been possible to obtain it, is given in the following order for each alumnus: Name, year in which the degree was conferred, degree, course, present occupation, and present mailing address.
Little is known about the nutrition or lipid metabolism of cold-water crabs, particularly in the North Pacific. We undertook a 2-part study to understand more completely the energetics and nutritional requirements of juvenile red king crab (RKC; Paralithodes canusehaticus). First, we investigated changes in proximate composition, total lipids (TLs), lipid...
Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....
Long period (10–20,000 s) magnetotelluric (MT) data are being acquired across the continental USA on a quasi-regular grid of ∼70 km spacing as an electromagnetic component of the National Science Foundation EarthScope/USArray Program. These data are sensitive to fluids, melts, and other organic indicators, and thus provide a valuable complement...