We report a novel cancer-targeted nanomedicine platform for imaging and prospect for future treatment of unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, novel low-oxygen graphene nanosheets were chemically modified with polypropylenimine dendrimers loaded with phthalocyanine (Pc) as a photosensitizer. Such a molecular design...
All existing sea otter, Enhydra lutris, populations have suffered at least one historic population bottleneck stemming from the fur trade extirpations of the eighteenth and nineteenth centuries. We examined genetic variation, gene flow, and population structure at five microsatellite loci in samples from five pre-fur trade populations throughout the sea...
Background: Transcriptome sequencing and assembly represent a great resource for the study of non-model species, and many metrics have been used to evaluate and compare these assemblies. Unfortunately, it is still unclear which of these metrics accurately reflect assembly quality.
Results: We simulated sequencing transcripts of Drosophila melanogaster. By assembling...
Climate change poses known and unknown risks for coastal communities and also challenges for university faculty and local government staff who communicate about climate sciences. Conceived as a way to move beyond traditional models of science communication, this project involved public and private decision makers in specific at-risk communities in...
Retreating glaciers and the periglacial areas they vacate for organismal colonization produce a harsh environment of extreme radiation, nutrient limitations, and temperature oscillations. They provide a model system for studying mechanisms that drive establishment and early assembly of communities. Here, we synthesize more than twenty years of research at the...
The dynamic Quaternary geology of the Pacific Ring of Fire created substantial challenges for biogeography. Fish life history and population genetic variation were shaped by climate change, repeated formation and subsidence of ice sheets, sea-level change, volcanism and tectonics, isostatic rebound, and now human activities. It is widely recognized in...
•Plant population genomics informs evolutionary biology, breeding, conservation and bioenergy feedstock development. For example, the detection of reliable phenotype–genotype associations and molecular signatures of selection requires a detailed knowledge about genome-wide patterns of allele frequency variation, linkage disequilibrium and recombination.
•We resequenced 16 genomes of the model tree Populus trichocarpa...
Non-structural carbohydrates (NSC) in plant tissue are frequently quantified to make inferences about plant responses to environmental conditions. Laboratories publishing estimates of NSC of woody plants use many different methods to evaluate NSC. We asked whether NSC estimates in the recent literature could be quantitatively compared among studies. We also...
In recent years the conservation community has engaged in debate over value in nonhuman nature, especially as it relates to motivations for conservation. Many have expressed the assumption that more people are willing to support conservation when emphasis is placed on the human benefits of nonhuman nature, rather than the...
The network comprising 61 high-frequency radar systems along the U.S. West Coast (USWC) provides a unique, high resolution, and broad scale view of ocean surface circulation. Subinertial alongshore surface currents show poleward propagating signals with phase speeds of O(10) and O(100–300) km d⁻¹ that are consistent with historical in situ...
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...
Objective. To examine the relationship between wealth and cardiovascular disease risk factors among Hispanic/Latinos of diverse backgrounds.
Design. This cross-sectional study used data from 4,971 Hispanic/Latinos, 18 to 74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) baseline exam and the HCHS/SOL Sociocultural Ancillary Study. Three...
New unified discovery tools are designed to help students easily identify and retrieve library content. Students want quick and easy discovery of quality sources in a “Google-like” environment. Librarians have often expressed frustration with federated and metasearch systems that cannot take full advantage of discipline specific database features. As new...
Oomycetes form a deep lineage of eukaryotic organisms that includes a large number of plant pathogens which threaten natural and managed ecosystems. We undertook a survey to query the community for their ranking of plant-pathogenic oomycete species based on scientific and economic importance. In total, we received 263 votes from...
In this paper we discuss the application of a range of techniques to the
verification of mission-critical flight software at NASA’s Jet Propulsion Laboratory.
For this type of application we want to achieve a higher level of confidence than can
be achieved through standard software testing. Unfortunately, given the current...
With the growth of Internet technologies, online-based foreign language curricula are being introduced at large numbers of institutions internationally. This peer-reviewed volume, geared towards a broad audience, presents innovative research on online language teaching, with chapters by highly engaged scholars and practitioners from the U.S. and Europe, with a strong...
We evaluate the impact of the Gambian hardship allowance, which provides a salary premium of 30‐40% to primary school teachers in remote locations, on the distribution and characteristics of teachers
across schools. A geographic discontinuity in the policy’s implementation and the presence of common
pre‐treatment trends between hardship and non‐hardship...