The debate over a coastal migration route for the First Americans revolves around two major points: seafaring technology, and a viable landscape and resource base. Three lake cores from Sanak Island in the western Gulf of Alaska yield the first radiocarbon ages from the continental shelf of the Northeast Pacific...
Alternative male phenotypes in salmonine fishes arise from individuals that mature as larger and older anadromous marine-migrants or as smaller and younger freshwater residents. To better understand the processes influencing the expression of these phenotypes we examined the influences of growth in length (fork length) and whole body lipid content...
Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells and model systems, endoxifen classically functions as an anti-estrogenic compound. Since estrogen...
Background: Scientists rarely reuse expert knowledge of phylogeny, in spite of years of effort to assemble a great
“Tree of Life” (ToL). A notable exception involves the use of Phylomatic, which provides tools to generate custom
phylogenies from a large, pre-computed, expert phylogeny of plant taxa. This suggests great potential...
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells...
Dendritic ecological networks (DENs) are a unique form of ecological networks that exhibit a dendritic network topology (e.g. stream and cave networks or plant architecture). DENs have a dual spatial representation; as points within the network and as points in geographical space. Consequently, some analytical methods used to quantify relationships...
The 2014 Working Group on California Earthquake Probabilities (WGCEP 2014) presents time-dependent earthquake probabilities for the third Uniform California Earthquake Rupture Forecast (UCERF3). Building on the UCERF3 time-independent model published previously, renewal models are utilized to represent elastic-rebound-implied probabilities. A new methodology has been developed that solves applicability issues in...
The 2014 Working Group on California Earthquake Probabilities
(WGCEP14) present the time-independent component of the Uniform California
Earthquake Rupture Forecast, Version 3 (UCERF3), which provides authoritative
estimates of the magnitude, location, and time-averaged frequency of potentially
damaging earthquakes in California. The primary achievements have been to relax
fault segmentation and...
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We
have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a
research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...