Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
We present a generalized estimating equations approach for estimating the concordance correlation coefficient and the
kappa coefficient from sample survey data. The estimates and their accompanying standard error need to correctly account
for the sampling design. Weighted measures of the concordance correlation coefficient and the kappa coefficient, along with
the...
Compared to conventional amorphous silicon (a-Si) TFTs, amorphous metal oxide TFTs have superior device performance such as
higher mobility, better sub-threshold swing, and lower off-state current. Amorphous metal oxide TFTs have an additional advantage
on the device uniformity due to the lack of grain boundary issues in the poly-Si TFTs....
Growth increment widths from hard structures of marine and freshwater fish and bivalve species are increasingly used to model growth and elucidate relationships with environmental variability. Fully characterizing the intrinsic age-related growth variation among individuals within and between populations, while estimating the extrinsic environmental effects simultaneously, can be challenging. Using...
The effect of non-zero, but small, viscosity and diffusivity on the marginal stability
of a stably stratified shear flow is examined by making perturbations around the
neutral solution for an inviscid and non-diffusive flow. The results apply to turbulent
flows in which horizontal and vertical turbulent transports of momentum and...
The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
Recent concerns about surface water quality near agricultural production areas have stimulated interest in “best management practices” to reduce the risk of off-site sediment, pesticide, and nutrient movement. Vegetative filter
strips can be one component of an integrated management system to reduce these risks.
We demonstrate a four-channel on-chip true-time-delay module based on a photonic crystal waveguide array. Using the photonic crystal taper to minimize the coupling loss, the delay lines with 1-3 mm long photonic crystal waveguides can operate up to a group index n(g) similar to ~23 without significant loss. The large...
We report thermal conductivities, thermal diffusivities, and volumetric heat capacities determined by a transient plane
heat source method for four whole-round core samples obtained by the Japan Trench Fast Drilling Project/Integrated
Ocean Drilling Program Expedition 343. These thermal properties are necessary for the interpretation of a temperature
anomaly detected in...
In this paper, we present the design, fabrication and characterization of a traveling
wave directional coupler modulator based on electro-optic polymer, which is able to provide
both high linearity and broad bandwidth. The high linearity is realized by introducing Δβ-reversal technique in the two-domain directional coupler. A travelling wave electrode...