Angiogenesis is an essential process for disease progression in many solid tumors. There are several major cascade events in the angiogenic process that can be targeted to inhibit new blood vessel formation in the tumor tissue. The purpose of this work is to evaluate the inhibitory effect of paclitaxel (PTX)...
PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in
poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic
processes and acute toxicity in mice was evaluated.
METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability,
and drug release. Cell proliferation, tubule...
Biodegradable poly(ethyleneglycol)-poly(valerolactone)-poly(ethyleneglycol) [PEG-PVL-PEG] copolymers were synthesized through ring opening polymerization of δ-valerolactone (VL) followed by the coupling of monomethoxy poly(ethyleneglycol-poly(valerolactone) (mPEG-PVL) with hexamethylene diisocyanate (HDI). The copolymers were characterized by ¹H NMR, FT-IR, and GPC. Block copolymers of PEG and PVL with different VL/PEG molar ratios were successfully synthesized. One...
Morphological and chemical studies of Hypogymnia from the Himalayas revealed one new species, three species new to the region, and a previously unrecognized synonym. Hypogymnia crystallina, distinguished by its rimmed holes in the lobe axils, a pruinose disc, POL+ epihymenium, and distinctive chemistry (zeorin, hypoprotocetraric acid, usnic acid and atranorin)...
Polymerase chain reaction (PCR) primers are reported for 68 nuclear-encoded microsatellites developed during the past several years from genomic libraries of red drum (Sciaenops ocelwtus). All68 microsatellites were tested for reproducibility and polymorphism on a sample of five to 12 red drum; 60 of the microsatellites were found to be...
Contextualization is a curricular approach and a learning process in which science content knowledge is intentionally situated within a context where that knowledge can be authentically applied or observed. Many recent science education reforms include contextualization as a central tenet. Our goal in this review was to examine commonalities across...
We examined 480 dissertations on the use of technology in mathematics education and developed a Quality Framework (QF) that provided structure to consistently define and measure quality. Dissertation studies earned an average of 64.4% of the possible quality points across all methodology types compared to studies in journals that averaged...
Budburst is a key adaptive trait that can help us understand how plants respond to a changing climate from the molecular to landscape scale. Despite this, acquisition of budburst data is constrained by a lack of information at the plant scale on the environmental stimuli associated with the release of...
One of the most significant challenges faced by hydrogeologic modelers is the disparity between the spatial and temporal scales at which fundamental flow, transport, and reaction processes can best be understood and quantified (e.g., microscopic to pore scales and seconds to days) and at which practical model predictions are needed...
Carnivore predation on livestock often leads people to retaliate. Persecution by humans has contributed strongly to global endangerment of carnivores. Preventing livestock losses would help to achieve three goals common to many human societies: preserve nature, protect animal welfare, and safeguard human livelihoods. Between 2016 and 2018, four independent reviews...