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Filtering by: Creator Cao, Limin Resource Type Article

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

Creator:

Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M., Seow, Yiqi, and Yin, HaiFang

Abstract:

Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...

Resource Type:

Article
Environmental limitation mapping of potential biomass resources across the conterminous United States

Creator:

Daly, Christopher, Halbleib, Michael D., Hannaway, David B., and Eaton, Laurence M.

Abstract:

Several crops have recently been identified as potential dedicated bioenergy feedstocks for the production of power, fuels, and bioproducts. Despite being identified as early as the 1980s, no systematic work has been undertaken to characterize the spatial distribution of their long-term production potentials in the United states. Such information is...

Resource Type:

Article