Clostridium difficile is the causative agent of the majority of antibiotic associated diarrheas. C.
difficile spores are recognized as the morphotype of transmission, infection and persistence.
However, there is a lack of knowledge on how C. difficile spores interact with the host’s
epithelial surfaces. In this context, we have characterized...
Background:
Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
The inter-relationships among δ¹³C and δ¹⁸O in tree ring cellulose and ring width have the potential to illuminate long-term physiological and environmental information in forest stands that have not been monitored. We examine how within-stand competition and environmental gradients affect ring widths and the stable isotopes of cellulose. We utilize...
The Penman‐Monteith equation is often used to estimate transpiration, but an important limitation to this approach, especially for mountainous forested sites, is an accurate estimate of canopy conductance averaged over the area of interest (Gs). We propose a method for estimating watershed‐scale transpiration using estimates of Gs derived from measurements...
Whether CaCO₃ dissolves within the top centimeters of marine sediments overlaid by deep, supersaturated bottom waters remains an area of debate in geochemistry. This uncertainty stems from the fact that different methods used to assess CaCO₃ dissolution rates often provide what appear to be profoundly different results. Here we combine...
Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded...
A globally integrated carbon observation and analysis
system is needed to improve the fundamental understanding
of the global carbon cycle, to improve our ability to
project future changes, and to verify the effectiveness of policies
aiming to reduce greenhouse gas emissions and increase
carbon sequestration. Building an integrated carbon observation...
Three months following sowing, Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) seedlings were transplanted into pots with controlled-release fertilizer (CRF) applied at rates of 0, 8, 16, and 24 g/2200 cm3 soil as a single uniform layer beneath the root system. Seedlings were destructively harvested periodically, and roots were divided into vertical...
Infection with Helicobacter pylori is a major risk factor for the development of gastric cancer, and infection with strains carrying the virulence factor CagA significantly increases this risk. To investigate the mechanisms by which CagA promotes carcinogenesis, we generated transgenic zebrafish expressing CagA ubiquitously or in the anterior intestine. Transgenic...
Purpose: Primary care practices are an ideal setting for reducing national smoking rates because >70% of smokers visit their physician annually, yet smoking cessation counseling is inconsistently delivered to patients. We designed and created a novel software program for handheld computers and hypothesized that it would improve clinicians' ability to...
Nitrogen incorporation from red alder (Alnus rubra Bong.) into an Oregon upland mesic forest soil was studied by tracing the fate of 15N added as 15N-labeled alder leaf litter. The recovery of 15N in vegetation, litter, light- and heavy-fractions of the soil, the chloroform-labile (microbial biomass) pool, and the whole...
Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10 [superscript -...
Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....
An experiment evaluating three levels of vegetation competition control (no control, 1.5 m2 of vegetation control, and 3.3 m2 of vegetation control), each with two fertilization treatments (fertilization at the time of planting with complete slow-release fertilizer (Woodace® IBDU), or no fertilization), was installed at five sites. Two of these...
Factors influencing soil organic matter (SOM) stabilization and dissolved organic carbon (DOC) content in complex terrain, where vegetation, climate, and topography vary over the scale of a few meters, are not well understood. We examined the spatial correlations of lidar and geographic information system-derived landscape topography, empirically measured soil characteristics,...
table isotope analysis is a powerful tool for assessing plant carbon and water relations and their impact on biogeochemical processes at different scales. Our process-based understanding of stable isotope signals, as well as technological developments, has progressed significantly, opening new frontiers in ecological and interdisciplinary research. This has promoted the...
Western diets are high in fat and sucrose and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can influence the brain and behavior. This study was designed to determine whether diet-induced changes in the gut microbiota could contribute to alterations in anxiety, memory or...
The effects of nitrogen (N) fertilizer application on plant growth, N uptake, and biomass and N allocation in highbush blueberry (Vaccinium corymbosum L. 'Bluecrop') were determined during the first 2 years of field establishment. Plants were either grown without N fertilizer after planting (0N) or were fertilized with 50, 100,...
A floristic study of marine macrophytic algae and Cyanobacteria in the splash and intertidal zones at Luhuitou reef, Sanya Bay, Hainan Island, China, was conducted during the rainy and dry seasons of 2008-2012 utilizing 148 of the most common species. Macrophytic algal diversity increased from the splash zone to the...
Although much is known about the effects of electroshock on fish physiology, consequences to the immune system and disease progression have not received attention. Our objectives were to determine the effects of electroshock on selected immune function in juvenile spring chinook salmon Oncorhynchus tshawytscha, the mechanism of any observed alteration,...
The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T. inflatum strain NRRL 8044 (ATCC 34921), the isolate from which cyclosporin was first isolated, is presented along with comparative analyses of the biosynthesis of...
Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous fundamental cellular...
Objective: To determine the relationship of motor skills and the core behaviors of young children with autism, social affective skills and repetitive behaviors, as indicated through the calibrated autism severity scores.
Design: The univariate GLM tested the relationship of gross and fine motor skills measured by the gross motor scale...
Motor skill deficits are present and persist in school-aged children with autism
spectrum disorder (ASD; Staples & Reid, 2010). Yet the focus of intervention is
on core impairments, which are part of the diagnostic criteria for ASD, deficits in
social communication skills. The purpose of this study is to determine...