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Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease

Creator:: Baarda, Benjamin I. and Sikora, Aleksandra E.
Abstract:: Neisseria gonorrhoeae is an exquisitely adapted, strictly human pathogen and the causative agent of the sexually transmitted infection gonorrhea. This ancient human disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. N. gonorrhoeae is rapidly evolving into a superbug...
Resource Type:: Article
Full Text:: old disease Benjamin I. Baarda and Aleksandra E. Sikora* Department of Pharmaceutical Sciences

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: Gonorrhea*□S Ryszard A. Zielke‡, Igor H. Wierzbicki‡, Benjamin I. Baarda‡, Philip R. Gafken§, Olusegun O

Biases in Thorpe-Scale Estimates of Turbulence Dissipation. Part I: Assessments from Large-Scale Overturns in Oceanographic Data

Creator:: Mater, Benjamin D., Venayagamoorthy, Subhas K., St Laurent, Louis, and Moum, James N.
Abstract:: Oceanic density overturns are commonly used to parameterize the dissipation rate of turbulent kinetic energy. This method assumes a linear scaling between the Thorpe length scale L[subscript]T and the Ozmidov length scale L[subscript]O. Historic evidence supporting L[subscript]T ~ L[subscript]O has been shown for relatively weak shear-driven turbulence of the thermocline;...
Resource Type:: Article
Full Text:: . Part I: Assessments from Large-Scale Overturns in Oceanographic Data Biases in Thorpe-Scale Estimates

Climate Feedbacks in CCSM3 under Changing CO₂ Forcing. Part I: Adapting the Linear Radiative Kernel Technique to Feedback Calculations for a Broad Range of Forcings

Creator:: Jonko, Alexandra K., Shell, Karen M., Sanderson, Benjamin M., and Danabasoglu, Gokhan
Abstract:: Climate feedbacks vary strongly among climate models and continue to represent a major source of uncertainty in estimates of the response of climate to anthropogenic forcings. One method to evaluate feedbacks in global climate models is the radiative kernel technique, which is well suited for model intercomparison studies because of...
Resource Type:: Article
Full Text:: Changing CO2 Forcing. Part I: Adapting the Linear Radiative Kernel Technique to Feedback Calculations for a

Five new species and three new subspecies of Erebidae and Noctuidae (Insecta, Lepidoptera) from Northwestern North America, with notes on Chytolita Grote (Erebidae) and Hydraecia Guenée (Noctuidae)

Creator:: Crabo, Lars G., Davis, Melanie, Hammond, Paul, Mustelin, Tomas, and Shepard, Jon
Abstract:: Several taxonomic issues in the moth families Erebidae and Noctuidae are addressed for Northwestern North America. Drasteria parallela Crabo & Mustelin and Cycnia oregonensis tristis Crabo in the Erebidae and Eudryas brevipennis bonneville Shepard & Crabo, Resapamea diluvius Crabo, Resapamea angelika Crabo, Resapamea mammuthus Crabo, Fishia nigrescens Hammond & Crabo,...
Resource Type:: Article
Full Text:: petrealis Grote with Herminea morbidalis Guenée; Gortyna columbia Barnes & Benjamin and Gortyna ximena

Enhancing the T-shaped learning profile when teaching hydrology using data, modeling, and visualization activities

Creator:: Sanchez, Christopher A., Ruddell, Benjamin L., Ruddell, Benjamin L., and Merwade, Venkatesh
Abstract:: Previous research has suggested that the use of more authentic learning activities can produce more robust and durable knowledge gains. This is consistent with calls within civil engineering education, specifically hydrology, that suggest that curricula should more often include professional perspective and data analysis skills to better develop the "T-shaped"...
Resource Type:: Article
Full Text:: visualization activities Christopher A. Sanchez1, Benjamin L. Ruddell2, Roy Schiesser3, and Venkatesh Merwade4

Urbanization causes increased cloud base height and decreased fog in coastal Southern California

Creator:: Williams, A. Park, Schwartz, Rachel E., Iacobellis, Sam, Seager, Richard, Cook, Benjamin I., Still, Christopher J., Husak, Gregory, and Michaelsen, Joel
Abstract:: Subtropical marine stratus clouds regulate coastal and global climate, but future trends in these clouds are uncertain. In coastal Southern California (CSCA), interannual variations in summer stratus cloud occurrence are spatially coherent across 24 airfields and dictated by positive relationships with stability above the marine boundary layer (MBL) and MBL...
Resource Type:: Article

Local Extinction and Unintentional Rewilding of Bighorn Sheep (Ovis canadensis) on a Desert Island

Creator:: Wilder, Benjamin T., Betancourt, Julio L., Epps, Clinton W., Crowhurst, Rachel S., Mead, Jim I., and Ezcurra, Exequiel
Abstract:: Bighorn sheep (Ovis canadensis) were not known to live on Tiburón Island, the largest island in the Gulf of California and Mexico, prior to the surprisingly successful introduction of 20 individuals as a conservation measure in 1975. Today, a stable island population of ~500 sheep supports limited big game hunting...
Resource Type:: Article

A technique for error estimation of linewidth and damping parameters extracted from ferromagnetic resonance measurements

Creator:: Buford, Benjamin, Dhagat, Pallavi, and Jander, Albrecht
Abstract:: Ferromagnetic resonance (FMR) characterization, using a vector network analyzer (VNA), is widely used to determine anisotropy, g-factor, and Gilbert damping parameter of magnetic thin films, but results are typically reported without calculation of the measurement accuracy. We present a method of processing VNA-FMR measurements to determine both the value and...
Resource Type:: Article
Full Text:: from ferromagnetic resonance measurements Benjamin Buford, Pallavi Dhagat, and Albrecht Jandera

ScholarsArchive@OSU

Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Biases in Thorpe-Scale Estimates of Turbulence Dissipation. Part I: Assessments from Large-Scale Overturns in Oceanographic Data

Climate Feedbacks in CCSM3 under Changing CO₂ Forcing. Part I: Adapting the Linear Radiative Kernel Technique to Feedback Calculations for a Broad Range of Forcings

Five new species and three new subspecies of Erebidae and Noctuidae (Insecta, Lepidoptera) from Northwestern North America, with notes on Chytolita Grote (Erebidae) and Hydraecia Guenée (Noctuidae)

Enhancing the T-shaped learning profile when teaching hydrology using data, modeling, and visualization activities

Urbanization causes increased cloud base height and decreased fog in coastal Southern California

Local Extinction and Unintentional Rewilding of Bighorn Sheep (Ovis canadensis) on a Desert Island

A technique for error estimation of linewidth and damping parameters extracted from ferromagnetic resonance measurements

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