In the Colorado Rocky Mountains, the association of high topography and low seismic
velocity in the underlying mantle suggests that recent changes in lithospheric buoyancy may have
been associated with surface uplift of the range. This paper examines the relationships among
late Cenozoic fluvial incision, channel steepness, and mantle velocity...
Neisseria gonorrhoeae is an exquisitely adapted, strictly human pathogen and the causative agent of the sexually transmitted infection gonorrhea. This ancient human disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. N. gonorrhoeae is rapidly evolving into a superbug...
Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...